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Future Applications of Large Language Models

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Computing and Artificial Intelligence".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 146

Special Issue Editors


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Guest Editor
Department of Law, Economics, Politics and Modern Languages, LUMSA University, 00193 Rome, Italy
Interests: machine learning applications; blockchain applications; network and service economics; healthcare management systems
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Department of Law, Economics, Politics and Modern Languages, LUMSA University of Rome, Via Pompeo Magno, 00192 Rome, Italy
Interests: machine learning; natural language processing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Large Language Models (LLMs) have demonstrated remarkable capabilities across diverse tasks, from text generation and translation to code synthesis and question-answering. However, their true potential lies beyond current applications and into the realm of complex, interactive AI systems. This Special Issue will explore the exciting future directions of LLM research, focusing on how these powerful models can be leveraged to create truly intelligent and helpful tools.

We are seeking contributions concerning any envisaged LLM application domain. A promising example is Explainable AI (XAI). While XAI is relatively mature in areas like text classification, its application to text generation remains nascent. Current approaches often rely on identifying and linking relevant text spans from the training corpus as "citations" for generated output. Another compelling direction is the agentic approach, which involves orchestrating multiple LLM instances (or prompts) to perform complex tasks. This has the potential to significantly broaden LLM applicability across general and specialized domains. Also, multimodal LLMs represent a key development area, capable of synergistic analysis of diverse data sources that are typically handled separately.

This Special Issue aims to bring together researchers from diverse fields, including Natural Language Processing, Artificial Intelligence, cognitive science, and human–computer interactions, to explore the transformative potential of LLMs. We encourage submissions presenting novel research, insightful perspectives, and innovative applications in these crucial areas, particularly those addressing explainability, agentic behavior, and multimodality.

Dr. Luigi Laura
Prof. Dr. Maurizio Naldi
Guest Editors

Dr. Paolo Fantozzi
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • large language models (LLMs)
  • LLM applications
  • generative AI
  • explainable AI (XAI)
  • natural language processing
  • artificial intelligence
  • human–computer interactions
  • agentic AI
  • multimodal AI

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Published Papers

This special issue is now open for submission.
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