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New Diagnostic and Therapeutic Approaches in Food Allergy, 2nd Edition

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 30 May 2026 | Viewed by 1499

Special Issue Editors


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Guest Editor
Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), 28040 Madrid, Spain
Interests: asthma; drug allergy; dendritic cell; basophil activation test
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, ‘New Diagnostic and Therapeutic Approaches in Food Allergy’.

Food allergy refers to an adverse reaction by the immune system triggered by harmless food-derived allergens. In recent years, the incidence of these allergic disorders has increased, becoming a serious social and economic burden worldwide. Although various studies and guidelines have emphasized that food allergies are more common in children than in adults, they can cause mild to severe symptoms in both groups, and can sometimes be life-threatening. Therefore, diagnosis and treatment are crucial in order to avoid food allergy reactions.

This Special Issue welcomes submissions of original research articles, clinical case reports, and reviews on the diagnosis and treatment of food allergies. Specific subject areas of interest include, but are not limited to, the following:

  • Specific mechanisms of food allergies (cellular and molecular).
  • Current clinical tips for food allergy diagnosis.
  • Novel methods for food allergy diagnosis.
  • Cellular and molecular biomarkers of food allergies.
  • The role of food tolerance acquisition.
  • The involvement of dendritic cells, T regulatory cells, and innate lymphoid cells in the mechanisms of food allergies.
  • New perspectives on allergen immunotherapy.
  • New approaches to desensitization for food allergies.
  • Monoclonal antibody therapies for the treatment of food allergies.
  • Clinical implications of food–pollen cross-reactivity.
  • Genetics and epigenetics related to food allergies.

Dr. José Antonio Canas
Dr. Blanca Cárdaba
Dr. Rubén Fernández-Santamaría
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food allergy
  • T2 response
  • IgE-mediated mechanisms
  • basophil activation test
  • immunotherapy

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Published Papers (1 paper)

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Review

16 pages, 928 KB  
Review
Autoimmune Protocol Diet (AIP) for Food Allergies: A Novel Immunonutrition Approach
by Eleni C. Pardali and Maria G. Grammatikopoulou
Appl. Sci. 2026, 16(3), 1364; https://doi.org/10.3390/app16031364 - 29 Jan 2026
Viewed by 1151
Abstract
The prevalence of allergies is increasing worldwide. In addition to pharmacological treatment, dietary management represents an established component of food allergy care. Elimination diets have long been recognized as an effective therapy for certain conditions, including food allergies. The Autoimmune Protocol (AIP) diet, [...] Read more.
The prevalence of allergies is increasing worldwide. In addition to pharmacological treatment, dietary management represents an established component of food allergy care. Elimination diets have long been recognized as an effective therapy for certain conditions, including food allergies. The Autoimmune Protocol (AIP) diet, a restrictive elimination diet originally developed for patients with autoimmune diseases, has gained popularity recently. Its underlying rationale, centered on immune regulation, intestinal epithelial barrier function, and gut dysbiosis, suggests potential relevance to food allergies. Moreover, the AIP excludes most of the major food allergens, which may support symptom reduction and facilitate the identification of individual dietary triggers. The role of histamine in allergic responses further highlights the AIP’s potential applicability in cases of histamine intolerance, where reducing the overall histamine burden could be beneficial. This narrative review aimed to synthesize the limited available evidence on the AIP and explore its potential implementation, mechanisms, and limitations in the context of food allergies. Full article
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