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New Technologies for Immunotherapy

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 30 December 2026 | Viewed by 1209

Special Issue Editors


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Guest Editor
Medical Sciences Faculty, Universidade do Estado do Rio de Janeiro, Campus Cabo Frio, Rio de Janeiro 28905-320, RJ, Brazil
Interests: immunology; cytokines; reactive oxygen species; cell signalling; macrophages

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Guest Editor
Laboratório de Biologia de Linfócitos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-972, Brazil
Interests: immunology; infectious disease; parasitology

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Guest Editor
1. Institute of Biology, University of Szczecin, Szczecin, Poland
2. Center for Experimental Immunology and Immunobiology in Infectious Diseases and Cancer, University of Szczecin, Szczecin, Poland
Interests: animal models; viral infections; immune system; innate immunity; T cells; flow cytometry; real-time PCR
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The immune system is critical for the elimination of harmful stimuli (infectious or not) and for the return and maintenance of homeostasis within the body. On the other hand, dysregulated and/or excessive activation of immune responses can be a leading cause of tissue damage and disease. In this Special Issue, we welcome studies that underscore how the manipulation of the immune response, whether to improve its antimicrobial or antitumoral activity or to restrain its deleterious effects, can be used to treat infectious and non-infectious diseases. The submitted studies should provide new approaches and/or technologies for immunotherapies, including (i) combined therapies; (ii) cellular therapies; (iii) repositioning of pharmaceuticals; (iv) new molecular targets or approaches that allows for the discovery of inedit treatment modalities; and related issues.  

Dr. Rafael Cardoso Maciel Costa Silva
Dr. Danielle Aparecida Sousa Rodrigues
Dr. Paulina Niedźwiedzka-Rystwej
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunotherapy
  • manipulation of immune responses
  • inflammatory damage

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Published Papers (1 paper)

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Review

42 pages, 2090 KB  
Review
Molecular Targets for Cancer Immunotherapy: Focusing on (Immune and Tumor) Cell-Derived Metabolites
by Rafaella Delatorre Tavares Quintans, Ângelo Azevedo de Freitas, Maynah Melo de Souza, Geovane Dias-Lopes and Rafael Cardoso Maciel Costa Silva
Appl. Sci. 2026, 16(5), 2461; https://doi.org/10.3390/app16052461 - 4 Mar 2026
Viewed by 742
Abstract
Tumor cells from different organs possess distinct metabolic requirements and develop in specific microenvironments. In this context, metabolites from the tumor microenvironment may impact the biology of tumors. Carbohydrates, lipids, and other metabolic intermediates exhibit important (and often contradictory) functions in the tumor [...] Read more.
Tumor cells from different organs possess distinct metabolic requirements and develop in specific microenvironments. In this context, metabolites from the tumor microenvironment may impact the biology of tumors. Carbohydrates, lipids, and other metabolic intermediates exhibit important (and often contradictory) functions in the tumor microenvironment. Here, several metabolites are discussed according to their role in both tumor and immune cell biology and how they can promote tumor growth or regression in distinct circumstances. In this context, numerous studies have highlighted that the combination of immunotherapies, including modulators of metabolic processes, emerges as a promising therapeutic strategy for treating distinct tumors. This combination might be especially important to impair the emergence of resistant clones of tumor cells and will be discussed in this review. Full article
(This article belongs to the Special Issue New Technologies for Immunotherapy)
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