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Computational Models and Machine Learning for Biomedical Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Computing and Artificial Intelligence".

Deadline for manuscript submissions: 30 August 2026 | Viewed by 516

Editors


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Guest Editor
Institute of Computer Science, University of Opole, 45-758 Opole, Poland
Interests: decision making systems; artificial intelligence; machine/deep learning; mathematical modeling and simulations; signal processing

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Guest Editor
Department of Artificial Intelligence, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland
Interests: machine learning; artificial intelligence; biomedical data processing; brain–computer interfaces; neurocomputing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to bring together cutting-edge research on computational models and machine learning methods that address key challenges in contemporary biomedicine and healthcare. We invite contributions that develop novel algorithms, robust computational frameworks, and clinically relevant applications for medical screening, diagnostic support, risk prediction, patient monitoring, and therapeutic decision-making.

We are particularly interested in studies that leverage recent advances in deep learning and foundation models, including large-scale and multimodal architectures that integrate imaging, biosignals, omics data, electronic health records, and clinical text. Topics of interest include, but are not limited to, medical image and signal analysis; computational pathology; genomics and other high-throughput omics; digital and personalized medicine; and AI-driven drug discovery and therapy optimization.

We also welcome contributions on multimodal and explainable AI, model robustness, uncertainty quantification, bias and fairness, privacy-preserving and federated learning, and methods designed for low-resource or real-time clinical settings. Studies connecting methodological innovation with experimental validation, clinical evaluation, open datasets, or reproducible software tools are strongly encouraged. This Special Issue aims to highlight reliable, transparent, and sustainable computational solutions that can advance biomedical research and improve healthcare outcomes.

Prof. Dr. Mariusz Pelc
Dr. Aleksandra Kawala-Sterniuk
Guest Editors

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Keywords

  • machine learning
  • deep learning
  • biomedical applications
  • medical imaging and signal processing
  • computational modeling
  • clinical decision support
  • multimodal data integration
  • explainable AI (XAI)
  • predictive analytics in healthcare
  • personalized and precision medicine

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Published Papers (1 paper)

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Research

25 pages, 4200 KB  
Article
Challenges in Emotion Recognition Across Modalities: A Comparative Analysis
by Rafał Gasz
Appl. Sci. 2026, 16(14), 7239; https://doi.org/10.3390/app16147239 - 20 Jul 2026
Viewed by 170
Abstract
Emotion recognition remains a challenging task despite substantial progress in machine learning and affective computing. This study examines challenges in emotion recognition through a comparative analysis of two widely used modalities: facial images and speech signals. The analysis was conducted using FER-2013 for [...] Read more.
Emotion recognition remains a challenging task despite substantial progress in machine learning and affective computing. This study examines challenges in emotion recognition through a comparative analysis of two widely used modalities: facial images and speech signals. The analysis was conducted using FER-2013 for facial emotion recognition and the TESS and RAVDESS datasets for speech emotion recognition. A MobileNetV2-based approach was applied to visual data, while speech analysis employed MFCC-based representations and both classical and deep learning models. The study combines quantitative performance evaluation with qualitative analysis of classification behavior, focusing on emotion-specific recognition difficulties and recurring error patterns across modalities. Model performance was assessed using accuracy, precision, recall, F1-score, and confusion matrices. Across the analysed datasets, overall classification accuracy ranged from approximately 73% to 96%, while class-level F1-scores ranged from 0.48 to 0.89 depending on the emotion and modality. Happiness and surprise consistently achieved the highest recognition performance, whereas neutral emotion, fear, and disgust exhibited the lowest class-level F1-scores and generated the highest numbers of misclassifications. The experimental results confirmed that happiness and surprise achieved the highest classification performance across modalities, while neutral emotion, fear, and disgust showed reduced recognition accuracy due to weak expressive cues and overlapping feature representations. These difficulties are associated with weak or ambiguous expressive signals, overlap between emotional categories, and variability in emotional expression. The comparative findings suggest that recognition challenges arise from both modality-specific limitations and the inherent properties of emotional expression. The results highlight the importance of multimodal approaches and more flexible representations for improving emotion recognition systems. Full article
(This article belongs to the Special Issue Computational Models and Machine Learning for Biomedical Applications)
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