The Antioxidant Effect of Melatonin on Mitochondrial Network
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 5290
Special Issue Editor
Interests: apoptosis; autophagy; oxidative stress; endopasmic reticulum stress; mitochondria
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Mounting evidence from current studies has indicated that oxidative stress contributes to the development of several diseases. Mitochondria are dynamic organelles that are involved in the regulation of various cellular functions, including energy production, ROS generation, and cell death. Recent papers have highlighted that mitochondria are remodeled by fission and fusion, which are a very important metabolic demand. Mitochondrial ROS can affect fission and fusion both under physiological and stress conditions. The ROS produced by the respiratory chain inside mitochondria could be involved in fission. This phenomenon, called mitoptosis, helps to maintain the mitochondrial morphology and function, eliminating ROS-producing mitochondria. There are many molecules that potentially work as free radical scavengers; however, melatonin has an advantageous position that other antioxidants do not have. In fact, melatonin directly or indirectly limits oxidative stress. Moreover, the protective effects of melatonin on mitochondria depend on its accumulation in these organelles. Several papers have documented that melatonin has positive effects on mitochondrial dynamics. However, the underlying mechanism through which melatonin regulates the mitochondrial network is still to be investigated. The aim of this Special Issue is to collocate original research in order to spread new knowledge to a broader audience of this journal.
Prof. Francesca Luchetti
Guest Editor
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Keywords
- • Melatonin • mitochondrial network • oxidative stress • apoptosis
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