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Antioxidants
Special Issues
Advances in Vitamin E Research
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Advances in Vitamin E Research

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 6868

Special Issue Editors

Prof. Dr. William L. Stone

E-Mail Website
Guest Editor
Department of Pediatrics, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Interests: vitamin E; tocopherols; tocotrienols; oxidative stress; cancer; pediatrics
Special Issues, Collections and Topics in MDPI journals
Dr. Victoria Palau

E-Mail Website
Guest Editor
Bill Gatton College of Pharmacy, Pharmaceutical Sciences, East Tennessee State University, Johnson City, TN 37614, USA
Interests: biological markers and cell signaling in oncogenesis; testing of novel compounds derived from plants with ethnobotanical importance
Dr. Hong Yong Peh

E-Mail Website
Guest Editor
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore
Interests: asthma; chronic obstructive pulmonary disease (COPD); vitamin E

Special Issue Information

Dear Colleagues,

Vitamin E research has progressively evolved from an early emphasis on alpha-tocopherol solely as a lipophilic antioxidant inhibiting lipid peroxidation and oxidative stress. Moreover, early research did not always distinguish between natural alpha-tocopherol (RRR-alpha) and synthetic alpha-tocopherol (all-racemic-alpha). We now recognize that the four tocopherols and the four tocotrienols that comprise the vitamin E vitamers have distinct chemical, stereochemical, and biochemical properties as well as functions independent of their roles as antioxidants. It is clear, for example, that the different vitamers of vitamin E can differentially modulate signal transduction pathways. Similarly, there is increasing evidence that the different vitamin E vitamers (and their metabolites) can uniquely modulate some disease processes. Even after decades of research, there remains much controversy around the risk/benefit ratio of vitamin E supplementation in cancer, cardiovascular disease, metabolic syndrome, type 2 diabetes, aging, and exercise physiology. Future basic, clinical, and kinesiological research will be needed to settle these issues and to further define the potential benefits of vitamin E vitamers.

For this Special Issue, we invite authors to submit novel work or reviews on the importance of advancing basic, clinical, and kinesiological vitamin E research. The topics include but are not limited to:

  • Vitamin E modulation of signal transduction pathways;
  • Risk/benefit of vitamin E supplementation in cancer;
  • Vitamin E’s role in cardiovascular disease;
  • Preventing metabolic syndrome;
  • Reducing oxidative stress driven type 2 diabetes;
  • Roles in aging and exercise physiology.

Prof. Dr. William L. Stone
Dr. Victoria Palau
Dr. Hong Yong Peh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vitamin E
  • absorption
  • metabolism and bioavailability
  • pharmacokinetics
  • antioxidant mechanisms
  • non-antioxidant activities
  • health and disease
  • industrial uses
  • functional properties
  • extraction and chemical characterization of metabolites

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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12 pages, 2197 KiB  
Article
Chronic Vitamin E Deficiency Dysregulates Purine, Phospholipid, and Amino Acid Metabolism in Aging Zebrafish Skeletal Muscle
by Trent D. Henderson, Jaewoo Choi, Scott W. Leonard, Brian Head, Robyn L. Tanguay, Carrie L. Barton and Maret G. Traber
Antioxidants 2023, 12(6), 1160; https://doi.org/10.3390/antiox12061160 - 26 May 2023
Cited by 5 | Viewed by 3190
Abstract
Muscle wasting occurs with aging and may be a result of oxidative stress damage and potentially inadequate protection by lipophilic antioxidants, such as vitamin E. Previous studies have shown muscular abnormalities and behavioral defects in vitamin E-deficient adult zebrafish. To test the hypothesis [...] Read more.
Muscle wasting occurs with aging and may be a result of oxidative stress damage and potentially inadequate protection by lipophilic antioxidants, such as vitamin E. Previous studies have shown muscular abnormalities and behavioral defects in vitamin E-deficient adult zebrafish. To test the hypothesis that there is an interaction between muscle degeneration caused by aging and oxidative damage caused by vitamin E deficiency, we evaluated long-term vitamin E deficiency in the skeletal muscle of aging zebrafish using metabolomics. Zebrafish (55 days old) were fed E+ and E− diets for 12 or 18 months. Then, skeletal muscle samples were analyzed using UPLC-MS/MS. Data were analyzed to highlight metabolite and pathway changes seen with either aging or vitamin E status or both. We found that aging altered purines, various amino acids, and DHA-containing phospholipids. Vitamin E deficiency at 18 months was associated with changes in amino acid metabolism, specifically tryptophan pathways, systemic changes in the regulation of purine metabolism, and DHA-containing phospholipids. In sum, while both aging and induced vitamin E deficiency did have some overlap in altered and potentially dysregulated metabolic pathways, each factor also presented unique alterations, which require further study with more confirmatory approaches. Full article
(This article belongs to the Special Issue Advances in Vitamin E Research)
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Review

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14 pages, 1272 KiB  
Review
Ameliorative Effect of Tocotrienols on Perimenopausal-Associated Osteoporosis—A Review
by Gengfan Liang, Audrey Siew Foong Kow, Chau Ling Tham, Yu-Cheng Ho and Ming Tatt Lee
Antioxidants 2022, 11(11), 2179; https://doi.org/10.3390/antiox11112179 - 3 Nov 2022
Cited by 7 | Viewed by 2810
Abstract
Osteoporosis, or bone loss, is a disease that affects many women globally. As life expectancy increases, the risk of osteoporosis in women also increases, too, and this will create a burden on the healthcare and economic sectors of a country. Osteoporosis was once [...] Read more.
Osteoporosis, or bone loss, is a disease that affects many women globally. As life expectancy increases, the risk of osteoporosis in women also increases, too, and this will create a burden on the healthcare and economic sectors of a country. Osteoporosis was once thought to be a disease that would occur only after menopause. However, many studies have shown that osteoporosis may develop even in the perimenopausal stage. Due to the erratic levels of estrogen and progesterone during the perimenopausal stage, studies suggest that women are exposed to the risk of developing osteoporosis even at this stage. The erratic hormonal changes result in the production of proinflammatory mediators and cause oxidative stress, which leads to the progressive loss of bone-building activities. Tocotrienols, members of vitamin E, have many health-promoting properties. Due to their powerful anti-oxidative and anti-inflammatory properties, tocotrienols have shown positive anti-osteoporotic properties in post-menopausal studies. Hence, we propose here that tocotrienols could also possibly alleviate perimenopausal osteoporosis by discussing in this review the connection between inflammatory mediators produced during perimenopause and the risk of osteoporosis. Tocotrienols could potentially be an anti-osteoporotic agent, but due to their low bioavailability, they have not been as effective as they could be. Several approaches have been evaluated to overcome this issue, as presented in this review. As the anti-osteoporotic effects of tocotrienols were mostly studied in post-menopausal models, we hope that this review could pave the way for more research to be done to evaluate their effect on peri-menopausal models so as to reduce the risk of osteoporosis from an earlier stage. Full article
(This article belongs to the Special Issue Advances in Vitamin E Research)
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