Bioactive Natural Compounds and Their Derivatives in Cancer: Redox Signaling, Molecular Mechanisms and Translational Opportunities
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 December 2026 | Viewed by 91
Special Issue Editors
Interests: bioactive natural compounds; terpenoids; semisynthetic derivatives; cancer; oxidative stress; apoptosis
2. Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain
Interests: role of genetic variants in modulating susceptibility to cancer; cancer-related complications and autoimmune diseases
Interests: synthesis; organic chemistry; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer remains one of the leading causes of mortality worldwide and continues to demand new therapeutic strategies with improved efficacy, selectivity, and mechanistic understanding. Bioactive natural compounds and their derivatives represent a rich source of chemically diverse molecules with promising anticancer potential. This Special Issue welcomes original research articles and reviews focused on natural compounds and semisynthetic or structurally optimized derivatives that modulate redox signaling, oxidative stress, inflammation, cell survival, and tumor progression. Topics of interest include medicinal chemistry, semisynthesis, structure–activity relationships, cytotoxicity, apoptosis, cell-cycle regulation, mitochondrial dysfunction, target identification, docking and other in silico approaches, as well as translational biomarkers of response and resistance in hematological malignancies and solid tumors. Interdisciplinary contributions bridging natural product chemistry, medicinal chemistry, molecular pharmacology, and translational oncology are particularly encouraged.
Dr. Fernando J. Reyes-Zurita
Dr. Juan Sainz
Prof. Dr. Rachid Chahboun
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bioactive natural compounds
- derivatives
- cancer
- redox signaling
- molecular mechanisms
- translational oncology
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