Redox and Inflammatory Regulation of Skeletal Muscle Mass and Function in Health and Disease

Dear Colleagues,

The numbers of people affected by non-transmissible chronic diseases and aging have increased in recent years and among the critical causes of these pathological states are inflammation and oxidative stress, imbalances between the formation of oxidant species, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), and antioxidant mechanisms. Many tissues, among them skeletal muscle, are exposed to oxidative stress and inflammation with harmful biological effects of ROS and inflammatory cytokines, such as alteration of muscle function and physiology. ROS can regulate several redox-sensitive signaling pathways that play a critical role in gene expression or protein modification. While oxidant species and inflammatory signals have gained much attention for their harmful effects on muscle contractibility, fatigue, and metabolic dysfunction, research has also shown ROS to facilitate muscle adaptation after stressors such as physical exercise.

We invite researchers and scientists to apply and contribute original research and review articles that reflect the progress in elucidating the mechanisms of the balance between ROS and cellular antioxidant machinery, their relationships with inflammation, and how they may be altered during muscle pathologies, emphasizing aging and chronic diseases. We welcome all articles that describe new and essential findings on the roles of oxidative stress and inflammation in sarcopenia, cachexia, myopathies, or any other muscle dysfunction. Submissions are expected that enable the expanding of knowledge and describe new strategies to treat or prevent a pathological status in which oxidative stress might be involved.

Prof. Dr. Claudio Cabello-Verrugio
Guest Editor

Manuscript Submission Information

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• skeletal muscle
• oxidative stress
• sarcopenia
• inflammation
• ROS
• redox signaling