Special Issue "Antioxidant Improvements by Nrf2 and PPAR Gamma Activation in Cardiovascular and Neurodegenerative Diseases"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 September 2021).

Special Issue Editors

Dr. Ima Dovinová
E-Mail Website
Guest Editor
Department of Experimental Hypertension, Centre of Experimental Medicine SAS, Institute of Normal and Pathological Physiology, Dúbravská cesta 9, 841 04 Bratislava, Slovak Republic
Prof. Dr. Julie Y.H. Chan
E-Mail Website
Guest Editor
Institute for Translational Research in Biomedicíne (ITRBM), Kaohsiung Chang Gung Memoriál Hospital, Kaohsiung 83301, Taiwan
Dr. Guliz Armagan
E-Mail Website
Co-Guest Editor
Department of Biochemistry, Faculty of Pharmacy, Ege University, 35040 İzmir, Turkey
Dr. Miroslav Barančík
E-Mail Website
Co-Guest Editor
Centre of Experimental Medicine SAS, Institute for Heart Research, Dúbravská cesta 9, 84104 Bratislava, Slovakia

Special Issue Information

Dear Colleagues,

Mammalian cells have evolved a unique strategy to protect themselves against oxidative damage induced by reactive oxygen species (ROS). The transcription factors nuclear factor erythroid 2-related factor 2  (Nrf2) and nuclear factor peroxisome proliferator-activated receptor γ (PPARγ) have been shown to play key roles in establishing this cellular antioxidative defense system. (...to play key roles in maintaining cellular redox homeostasis via the activation of antioxidant defense systems).

Nrf2 (or NFE2L2) functions as a target nuclear receptor against oxidative stress (...functions as a ubiquitous, evolutionarily conserved intracellular defense mechanism to counteract oxidative stress) and is a key factor in redox regulation in hypertension, cardiovascular, and neurodegenerative diseases. The Keap1-Nrf2-ARE (antioxidant response element ) system regulates many detoxifying and antioxidant enzymes in cells after the exposure to reactive oxygen species and electrophiles. Activation of Nrf2/ARE signaling is differentially regulated during acute and chronic stress.

PPARγ is a nuclear receptor playing an important role in the management of cardiovascular diseases, hypertension, and metabolic syndrome. PPARγ targets genes with peroxisome proliferator response element (PPRE), leading to the identification of several genes involved in lipid metabolism or oxidative stress. PPARγ stimulation is triggered by endogenous and exogenous ligands–agonists, and it is involved in the activation of several cellular signaling pathways involved in oxidative stress response, such as the PI3K/Akt/NOS pathway.

Nrf2 and PPARγ pathways seem to be connected by a positive feedback loop, which maintains the expression of both transcription factors and their target antioxidant genes in a simultaneous manner. Moreover, Nrf2 and PPARγ are linked together through effects of their several activators. The importance of  Nrf2/ARE and PPARγ/PPRE pathways is supported by the fact both play an important role in the control of cardiovascular and neurodegenerative diseases.

Dr. Ima Dovinová
Prof. Dr. Julie Y.H. Chan
Dr. Guliz Armagan
Dr. Miroslav Barančík
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Oxidative stress
  • Nrf2
  • PPARγ
  • Antioxidants
  • Redox regulation
  • Cardiovascular disease
  • Neurodegenerative disease

Published Papers

There is no accepted submissions to this special issue at this moment.
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