Special Issue "NO-Donors with Antioxidant Activities"

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 2962

Special Issue Editors

Prof. Dr. Loretta Lazzarato
E-Mail Website
Guest Editor
Department of Drug Science and Technology, Università degli Studi di Torino, via Pietro Giuria 9, 10125 Torino, Italy
Interests: nitric oxide; nitric oxide donors; nitric oxide photodonors; multidrug resistance; anticancer drugs; photodynamic therapy; medicinal chemistry

Special Issue Information

Dear Colleagues,

Nitric oxide (NO) is a gaseous endogenous messenger ubiquitous in mammalian tissues, controlling a broad array of physiological and pathological processes in the cardiovascular system, in the central and peripheral nervous systems. It is one of the final effectors of the immune system. NO is a multitarget species able to attack proteins, lipids and DNA. The biological effects of NO are strictly dependent on its concentration and on its localization site. The action of NO and of its derivatives, which takes place after reaction with O2, could occur by different mechanisms. Among them, the possible formation of highly reactive species such as ONOO and HO•, which can cause oxidative damage. Low levels of NO inhibit apoptosis; while high levels of NO promote apoptosis directly through nitrosylation of crucial mitochondrial enzymes, or indirectly, via oxidative and nitrosative stress resulting from the formation of reactive nitrogen species (RNS). NO properties has been exploited in anticancer therapy in particular since there is evidence that it can overcome drug resistance. In view of the great potentiality of NO in cancer therapy some important NO-donors were hybridized with currently used anti-tumour drugs in order to develop new more potent anticancer agents.

This Special Issue aims to collect papers or reviews dealing with all aspects of NO-donors, alone, conjugated or hybridized with other compounds in order to obtain synergistic or additive effects. Studies examining with particular attention the antioxidant/pro-oxidant activities in vitro or in vivo of RNS produced by the compounds are especially welcome.

Prof. Dr. Loretta Lazzarato

Prof. Chiara Riganti
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nitric oxide donors
  • Antioxidants
  • Multidrug resistance
  • Oxidative stress

Published Papers (2 papers)

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Research

Article
Multitarget Antioxidant NO-Donor Organic Nitrates: A Novel Approach to Overcome Nitrates Tolerance, an Ex Vivo Study
Antioxidants 2022, 11(1), 166; https://doi.org/10.3390/antiox11010166 - 16 Jan 2022
Cited by 1 | Viewed by 787
Abstract
Chronic use of glyceryl trinitrate (GTN) is limited by serious side effects, such as tolerance and endothelial dysfunction of coronary and resistance arteries. Although GTN is used as a drug since more than 130 years, the mechanisms of the vasodilatory effects and of [...] Read more.
Chronic use of glyceryl trinitrate (GTN) is limited by serious side effects, such as tolerance and endothelial dysfunction of coronary and resistance arteries. Although GTN is used as a drug since more than 130 years, the mechanisms of the vasodilatory effects and of tolerance development to organic nitrates are still incompletely elucidated. New synthesized organic nitrates with and without antioxidant properties were characterized for their ex vivo tolerance profile, in order to investigate the oxidative stress hypothesis of nitrate tolerance. The organic nitrates studied showed different vasodilation and tolerance profiles, probably due to the ability or inability of the compounds to interact with the aldehyde dehydrogenase-2 enzyme (ALDH-2) involved in bioactivation. Furthermore, nitrooxy derivatives endowed with antioxidant properties did not determine the onset of tolerance, even if bioactivated by ALDH-2. The results of this study could be further evidence of the involvement of ALDH-2 in the development of nitrate tolerance. Moreover, the behavior of organic nitrates with antioxidant properties supports the hypothesis of the involvement of ROS in inactivating ALDH-2. Full article
(This article belongs to the Special Issue NO-Donors with Antioxidant Activities)
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Article
Nitric Oxide Ameliorates Plant Metal Toxicity by Increasing Antioxidant Capacity and Reducing Pb and Cd Translocation
Antioxidants 2021, 10(12), 1981; https://doi.org/10.3390/antiox10121981 - 13 Dec 2021
Cited by 5 | Viewed by 1608
Abstract
Recently, nitric oxide (NO) has been reported to increase plant resistance to heavy metal stress. In this regard, an in vitro tissue culture experiment was conducted to evaluate the role of the NO donor sodium nitroprusside (SNP) in the alleviation of heavy metal [...] Read more.
Recently, nitric oxide (NO) has been reported to increase plant resistance to heavy metal stress. In this regard, an in vitro tissue culture experiment was conducted to evaluate the role of the NO donor sodium nitroprusside (SNP) in the alleviation of heavy metal toxicity in a bamboo species (Arundinaria pygmaea) under lead (Pb) and cadmium (Cd) toxicity. The treatment included 200 µmol of heavy metals (Pb and Cd) alone and in combination with 200 µM SNP: NO donor, 0.1% Hb, bovine hemoglobin (NO scavenger), and 50 µM L-NAME, N(G)-nitro-L-arginine methyl ester (NO synthase inhibitor) in four replications in comparison to controls. The results demonstrated that the addition of L-NAME and Hb as an NO synthase inhibitor and NO scavenger significantly increased oxidative stress and injured the cell membrane of the bamboo species. The addition of sodium nitroprusside (SNP) for NO synthesis increased antioxidant activity, protein content, photosynthetic properties, plant biomass, and plant growth under heavy metal (Pb and Cd) toxicity. It was concluded that NO can increase plant tolerance for metal toxicity with some key mechanisms, such as increasing antioxidant activities, limiting metal translocation from roots to shoots, and diminishing metal accumulation in the roots, shoots, and stems of bamboo species under heavy metal toxicity (Pb and Cd). Full article
(This article belongs to the Special Issue NO-Donors with Antioxidant Activities)
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