Special Issue "NO-Donors with Antioxidant Activities"
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 2962
Interests: nitric oxide; nitric oxide donors; nitric oxide photodonors; multidrug resistance; anticancer drugs; photodynamic therapy; medicinal chemistry
Interests: multidrug resistance; immune-resistance; immune-evasion; cancer metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue in International Journal of Molecular Sciences: New Strategies to Overcome Resistance to Chemotherapy and Immune System in Cancer 2.0
Special Issue in Cancers: New Diagnostic and Therapeutic Tools Against Multidrug Resistant Tumors (STRATAGEM Special Issue, EU-COST CA17104)
Special Issue in International Journal of Molecular Sciences: New Strategies to Overcome Resistance to Chemotherapy and Immune System in Cancer 3.0
Special Issue in Cancers: New Diagnostic and Therapeutic Tools against Multidrug Resistant Tumors 2.0 (STRATAGEM Special Issue, EU-COST CA17104)
Nitric oxide (NO) is a gaseous endogenous messenger ubiquitous in mammalian tissues, controlling a broad array of physiological and pathological processes in the cardiovascular system, in the central and peripheral nervous systems. It is one of the final effectors of the immune system. NO is a multitarget species able to attack proteins, lipids and DNA. The biological effects of NO are strictly dependent on its concentration and on its localization site. The action of NO and of its derivatives, which takes place after reaction with O2, could occur by different mechanisms. Among them, the possible formation of highly reactive species such as ONOO− and HO•, which can cause oxidative damage. Low levels of NO inhibit apoptosis; while high levels of NO promote apoptosis directly through nitrosylation of crucial mitochondrial enzymes, or indirectly, via oxidative and nitrosative stress resulting from the formation of reactive nitrogen species (RNS). NO properties has been exploited in anticancer therapy in particular since there is evidence that it can overcome drug resistance. In view of the great potentiality of NO in cancer therapy some important NO-donors were hybridized with currently used anti-tumour drugs in order to develop new more potent anticancer agents.
This Special Issue aims to collect papers or reviews dealing with all aspects of NO-donors, alone, conjugated or hybridized with other compounds in order to obtain synergistic or additive effects. Studies examining with particular attention the antioxidant/pro-oxidant activities in vitro or in vivo of RNS produced by the compounds are especially welcome.Prof. Dr. Loretta Lazzarato
Prof. Chiara Riganti
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Nitric oxide donors
- Multidrug resistance
- Oxidative stress