Lipid Peroxidation: Molecular Mechanisms and Systemic Responses
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Aberrant Oxidation of Biomolecules".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 211
Special Issue Editor
Interests: oxidative stress; lipid peroxidation; redox proteomics; metabolic profiling; toxicology; inflammation; metabolic syndrome; carcinogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cellular redox homeostasis is tightly regulated to sustain normal cellular function and physiological processes. However, diverse endogenous and exogenous factors can disrupt this balance resulting in oxidative stress. Under such conditions, excessive production of reactive oxygen species may damage polyunsaturated fatty acids within biological membranes, initiating a chain reaction of lipid peroxidation. Lipid peroxidation yields a broad spectrum of bioactive products whose effects extend far beyond local membrane damage.
In addition to well-characterized lipid peroxidation end products such as 4-hydroxynonenal and malondialdehyde, lipid peroxidation gives rise to diverse oxidized lipid species, including oxidized phospholipids and oxylipins, which play important roles in both physiological and pathological contexts. The lipid peroxidation-derived products are involved in redox and cellular signaling, inflammation, metabolic regulation and disease progression. Increasing evidence suggests that these lipid-derived species contribute not only to cellular dysfunction and regulated cell death pathways but also to broader systemic alterations, including tissue remodeling and changes in the composition and biological activity of circulating extracellular vesicles under conditions of oxidative stress.
By bringing together original research articles and comprehensive reviews, this Special Issue aims to provide an integrative overview of the multifaceted roles of lipid peroxidation in oxidative stress-associated cellular, tissue and systemic responses. Contributions will address molecular mechanisms, biomarker discovery and translational implications of lipid peroxidation in health and disease, including cancer, aging, neurodegeneration and metabolic disorders.
Dr. Morana Jaganjac
Guest Editor
Manuscript Submission Information
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Keywords
- redox homeostasis
- lipid peroxidation
- cellular function
- tissue remodeling
- systemic alterations
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