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Antioxidants
Special Issues
Oxidative Stress-Mediated Vascular Disease
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Oxidative Stress-Mediated Vascular Disease

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 714

Special Issue Editor

Dr. Yuri Korystov

E-Mail Website
Guest Editor
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia
Interests: oxidative stress; vessels; atherosclerosis; ionizing radiation; diabetes mellitus; flavonoids; determination of ROS and ACE in vessels

Special Issue Information

Dear Colleagues,

I was born in Russia in 1948. I graduated from the biological faculty of Moscow State University in 1973 and passed a post-graduate course at the Institute of Biological Physics in Pushchino. I received the Cand. Sc. degree in 1978. In 1989, I defended my thesis “The mechanisms of participation of oxygen in radiation-induced inactivation of cells” and subsequently received the Dr. Sc. degree. I have been the head of the laboratory of oxidative stress since 1990. My main areas of research interests are: oxidative stress, vessels, atherosclerosis, ionizing radiation, diabetes mellitus, flavonoids, determination of ROS and ACE in vessels. The topics of this special issue are the causes of oxidative stress in vessels (infection, ionizing radiation, diabetes mellitus, metabolic abnormalities and so on) and role of ROS in atherosclerosis.  

Dr. Yuri Korystov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aorta
  • ACE
  • flavonoids
  • oxidative stress
  • ROS

Published Papers (1 paper)

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Review

18 pages, 3616 KiB  
Review
Dose-Dependent Effects of Lipopolysaccharide on the Endothelium—Sepsis versus Metabolic Endotoxemia-Induced Cellular Senescence
by Dennis Merk, Fiona Frederike Cox, Philipp Jakobs, Simone Prömel, Joachim Altschmied and Judith Haendeler
Antioxidants 2024, 13(4), 443; https://doi.org/10.3390/antiox13040443 - 9 Apr 2024
Viewed by 521
Abstract
The endothelium, the innermost cell layer of blood vessels, is not only a physical barrier between the bloodstream and the surrounding tissues but has also essential functions in vascular homeostasis. Therefore, it is not surprising that endothelial dysfunction is associated with most cardiovascular [...] Read more.
The endothelium, the innermost cell layer of blood vessels, is not only a physical barrier between the bloodstream and the surrounding tissues but has also essential functions in vascular homeostasis. Therefore, it is not surprising that endothelial dysfunction is associated with most cardiovascular diseases. The functionality of the endothelium is compromised by endotoxemia, the presence of bacterial endotoxins in the bloodstream with the main endotoxin lipopolysaccharide (LPS). Therefore, this review will focus on the effects of LPS on the endothelium. Depending on the LPS concentration, the outcomes are either sepsis or, at lower concentrations, so-called low-dose or metabolic endotoxemia. Sepsis, a life-threatening condition evoked by hyperactivation of the immune response, includes breakdown of the endothelial barrier resulting in failure of multiple organs. A deeper understanding of the underlying mechanisms in the endothelium might help pave the way to new therapeutic options in sepsis treatment to prevent endothelial leakage and fatal septic shock. Low-dose endotoxemia or metabolic endotoxemia results in chronic inflammation leading to endothelial cell senescence, which entails endothelial dysfunction and thus plays a critical role in cardiovascular diseases. The identification of compounds counteracting senescence induction in endothelial cells might therefore help in delaying the onset or progression of age-related pathologies. Interestingly, two natural plant-derived substances, caffeine and curcumin, have shown potential in preventing endothelial cell senescence. Full article
(This article belongs to the Special Issue Oxidative Stress-Mediated Vascular Disease)
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