Innovative Approaches to Neuroprotective Strategies: Targeting Oxidative Stress in Neurodegenerative Disorders
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 5
Special Issue Editor
Special Issue Information
Dear Colleagues,
Oxidative stress, defined as an imbalance between the production of reactive oxygen species (ROS) and the capacity of antioxidant defense systems, plays a central role in the onset and progression of neurodegenerative diseases. Neurons are particularly vulnerable to oxidative damage due to their high metabolic activity, lipid-rich membranes, and limited regenerative capacity. Excessive ROS can lead to mitochondrial dysfunction, impaired homeostasis, DNA damage, and the activation of pro-death signaling cascades, all contributing to the loss of neuronal integrity and function seen in disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Recent advances in neurobiology and redox research have highlighted novel therapeutic strategies aimed at reducing oxidative damage or enhancing endogenous antioxidant responses. These include small-molecule antioxidants, natural compounds, redox-active nanoparticles, gene therapies, and modulators of redox-sensitive signaling pathways.
We invite you to submit your latest research findings or a review article to this Special Issue, which should explore innovative neuroprotective strategies that target oxidative stress in both physiological and pathological contexts. Suitable topics of interest include, but are not limited to, the following: the molecular basis of redox imbalance in the nervous system; mitochondrial-targeted antioxidants; ROS-related signaling in neurodegeneration; antioxidant-based therapeutics; and translational models of redox-targeted interventions.
Dr. Tomasz Boczek
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative stress
- neurodegeneration
- antioxidant therapy
- mitochondrial dysfunction
- redox signaling
- reactive oxygen species (ROS)
- neuroprotection
- Alzheimer’s disease
- Parkinson’s disease
- translational neuroscience
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