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Special Issue "Structure and Function of Antibodies"
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (30 April 2019).
Department of Creative Research, Biomolecular Organization Research Group, Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki, Japan
Interests: biomolecular ordering; glycobiophysics; biomolecular NMR spectroscopy
This Special Issue aims to review the current knowledge in the field of immunotherapy with a view to providing insight that may inform the next generation of antibody therapeutics. The design and clinical application of monoclonal antibody (mAb) therapeutics requires a comprehensive understanding of the intimate relationship between structure and function. Continued reports of adverse reactions and/or loss of efficacy are evidence of the need for a deeper and more precise understanding of sequelae following immune intervention(s); however, the unique structure of a mAb may inevitably result in elicitation of anti-drug antibodies (ADA), at least in a proportion of patients. Further insights into the mechanisms of action (MoA) in vivo require the elucidation of parameters that determine the “architecture” of the immune complexes formed, e.g., epitope specificity, affinity, isotype, etc. Advances towards the generation of structurally homogeneous mAbs, e.g., glycoforms, may be realised through cell engineering to control/regulate intracellular pathways, e.g., post-translational modifications. Next Generation Sequencing (NGS) reveals individual and population polymorphisms within immune repertoires, e.g., the antibody variable region and cellular receptor genes that may be relevant to patient stratification and the pursuit of personalized medicine. The armamentarium should be extended beyond IgG to include the other antibody isotypes, e.g., IgA, IgM, and IgE.Prof. Dr. Roy Jefferis
Prof. Dr. William R. (Bill) Strohl
Prof. Dr. Koichi Kato
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Ig genes
- Orthogonal physico-chemical techniques
- IgG 3-D structure
- Antibody paratopes
- IgG subclasses
- Mechanisms of action