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IMGT® and 30 Years of Immunoinformatics Insight in Antibody V and C Domain Structure and Function

IMGT®, the international ImMunoGeneTics information system®, University of Montpellier, CNRS, Laboratoire d’ImmunoGénétique Moléculaire LIGM, Institut de Génétique Humaine IGH, UMR 9002 CNRS-UM, 141 rue de la Cardonille, 34396 Montpellier CEDEX 5, France
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Antibodies 2019, 8(2), 29; https://doi.org/10.3390/antib8020029
Received: 13 March 2019 / Revised: 29 March 2019 / Accepted: 9 April 2019 / Published: 11 April 2019
(This article belongs to the Special Issue Structure and Function of Antibodies)
At the 10th Human Genome Mapping (HGM10) Workshop, in New Haven, for the first time, immunoglobulin (IG) or antibody and T cell receptor (TR) variable (V), diversity (D), joining (J), and constant (C) genes were officially recognized as ‘genes’, as were the conventional genes. Under these HGM auspices, IMGT®, the international ImMunoGeneTics information system®, was created in June 1989 at Montpellier (University of Montpellier and CNRS). The creation of IMGT® marked the birth of immunoinformatics, a new science, at the interface between immunogenetics and bioinformatics. The accuracy and the consistency between genes and alleles, sequences, and three-dimensional (3D) structures are based on the IMGT Scientific chart rules generated from the IMGT-ONTOLOGY axioms and concepts: IMGT standardized keywords (IDENTIFICATION), IMGT gene and allele nomenclature (CLASSIFICATION), IMGT standardized labels (DESCRIPTION), IMGT unique numbering and IMGT Collier de Perles (NUMEROTATION). These concepts provide IMGT® immunoinformatics insights for antibody V and C domain structure and function, used for the standardized description in IMGT® web resources, databases and tools, immune repertoires analysis, single cell and/or high-throughput sequencing (HTS, NGS), antibody humanization, and antibody engineering in relation with effector properties. View Full-Text
Keywords: IMGT; immunoinformatics; immunogenetics; IMGT-ONTOLOGY; IMGT Collier de Perles; IMGT unique numbering; immunoglobulin; antibody; paratope; complementarity determining region IMGT; immunoinformatics; immunogenetics; IMGT-ONTOLOGY; IMGT Collier de Perles; IMGT unique numbering; immunoglobulin; antibody; paratope; complementarity determining region
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Lefranc, M.-P.; Lefranc, G. IMGT® and 30 Years of Immunoinformatics Insight in Antibody V and C Domain Structure and Function. Antibodies 2019, 8, 29.

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