Antibiotic Use in Clostridioides difficile Infection, Mechanisms of Resistance and Alternative Treatments
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (15 October 2024) | Viewed by 381
Special Issue Editors
Interests: C. difficile; epidemiology; virulence; genomics; proteomics; alternative treatments for CDI
Interests: Clostridioides difficile infection; antimicrobial resistance; antimicrobial treatment; immune response; host-pathogen interaction; human gut microbiota; infection control
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Clostridioides difficile is the most common pathogen responsible for hospital-associated diarrhea, with recurrence becoming a serious issue in healthcare institutions due to its evasion of existing treatment strategies. Undoubtedly, the evolution of antimicrobials has altered the epidemiology of C. difficile, which is currently regarded as one of the top five urgent antibiotic resistance problems in the United States. C. difficile antibiotic resistance mechanisms are constantly changing and influencing the fitness of the pathogen. The mechanisms involved in C. difficile resistance to antimicrobials are crucial for changing antibiotic directrices in hospitals, as well identifying alternative treatments and searching for new therapeutic targets to prevent C. difficile infection (CDI). So far, various antimicrobial resistance mechanisms have been described in C. difficile, including target site modification, drug change, efflux pumps and the existence of conjugative plasmids, which have been associated to metronidazole and vancomycin resistance. This Special Issue welcomes manuscript contributions that advance our understanding of antibiotic resistance in C. difficile and alternative CDI therapies.
Dr. Eliane De Oliveira Ferreira
Dr. Guido Granata
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
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Keywords
- Clostridioides difficile
- antibiotics
- resistance mechanisms
- treatment
- new therapies
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