Staphylococci Antimicrobial Tolerance, Persistent Infection and Antimicrobial Strategies
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".
Deadline for manuscript submissions: closed (30 October 2023) | Viewed by 4339
Special Issue Editors
Interests: Staphylococcus aureus; persistent infection; biofilm; evolution
Interests: Staphylococcus aureus; drug resistance; small colony formation
Special Issue Information
Dear Colleagues,
Staphylococci are pathogens causing a vast array of infections with significant mortality in humans. These organisms can infect virtually any tissue of the body. Moreover, they readily grow on artificial surfaces of implanted devices such as prosthetic heart valves and intravascular and urinary catheters. They were designated as a “persistent pathogen” due to their unusual recalcitrance towards antibiotic treatment, which to date has remained a major clinical challenge. Current antibiotics present a reduced capacity to eradicate staphylococci in abscesses or implant infections without surgical support . Physicians choose antibiotics according to a strain’s MIC as determined with susceptibility tests in vitro. However, antimicrobial therapy frequently fails despite susceptibility in standard microbiological assays. Emerging evidence indicates that the ability of staphylococci to become antibiotic-tolerant through versatile physiological changes within their host represents a major microbiological reason for the high rate of treatment failure. The application of “omics” technology to investigate staphylococcal physiological change mechanisms during infections helps us to understand the triggers of increased antibiotic survival in the context of various types of infection and life forms of the staphylococci. Due to a growing awareness of increased antibiotic survival, a great deal of research has turned its focus to new ways of treating and eradicating tolerant staphylococci. However, more studies are needed to better understand the dynamics, mechanisms and relevance of tolerant staphylococci at the site of infection and advance the fight against one of mankind’s enduring foes. This Special Issue seeks manuscript submissions that further our understanding of advanced Staphylococci antimicrobial tolerance, persistent infection and antimicrobial strategies.
Prof. Dr. Lei He
Prof. Dr. Xiancai Rao
Prof. Dr. Yan Chen
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- staphylococcal infection
- persistent pathogen
- implant infection
- biofilm
- antibiotic tolerance
- SCV
- phenotypic tolerance
- persister
- antimicrobial strategies
- genomics
- within-host evolution
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
