Emerging Treatment Options for Multidrug-Resistant Bacterial and Fungal Infections, 2nd Edition

Dear Colleagues,

Infections by multidrug-resistance (MDR) pathogens are related to increased morbidity, mortality, in-hospital length of stay, and healthcare costs. The emergence of pathogenic microorganisms which cannot be effectively treated with existing drugs has been prioritized by the World Health Organization as one of the top ten global public health threats facing humanity. It has been reported that, without interventions, by the year 2050, 10 million people will die annually as a consequence of MDR infections, unless a global and effective response is achieved to tackle the problem. MDR Gram-negative Enterobacterales, MRSA, and VRE represent cumbersome to treat infections especially in a hospital setting as well as for more vulnerable patients such as those in ICU, where MDR bacteria and fungi could deteriorate the precarious patient clinical conditions. Furthermore, in these delicate settings, emerging MDR Candida spp. strains represent a rising dramatic phenomenon. The growing spread of MDR pathogens needs to be tackled by further research and new approaches in microbiological techniques that will enable the fast identification of resistance patterns; clinical management which assures the best diagnostic pathways avoiding useless antimicrobial therapies and performing the correct source control, and pharmacological options that could target pathogen-specific resistance mechanism avoiding drugs superfluous exposition and adverse events.

This Special Issue aims to collect original articles, literature reviews, and case reports/case series about emerging treatment options against MDR bacteria and fungi, with particular interest in new antibiotics and drug combination.

Dr. Andrea Marino
Dr. Stefano Stracquadanio
Guest Editors

Manuscript Submission Information

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• MDR bacteria
• antibiotic resistance
• new antimicrobial
• MDR fungi
• antifungal therapies
• alternative strategies

• Emerging Treatment Options for Multidrug-Resistant Bacterial and Fungal Infections in Antibiotics (9 articles)