Membranes to Fight Drug-Resistant Microbes
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Peptides".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 12452
Special Issue Editor
Interests: membrane-active compounds; antimicrobial peptides; anti-cancer peptides; lipid-peptide interactions; membrane-compound interaction; drug design
Special Issue Information
Dear Colleagues,
In the fight for finding possible ways to combat multidrug resistance, microbial membranes play a central role. Every microorganism is enveloped with a membrane, which gives them not only a unique character but protection that is essential for survival. The interruption of this fundamental barrier function leads to a rapid cell death and killing rate that is usually faster than the microbial growth rate. Such a non-specific mode of action is less likely to result in resistance and, amongst others, is effective on a variety of microbes, including bacteria, fungi, biofilms, and membrane-enveloped viruses. Compounds disrupting or acting on microbial membranes are generally termed as membrane-active and examples include antimicrobial peptides (AMPs), lipidoids, or many other small molecules, such as quaternary ammonium compounds. The mechanism behind the killing of microorganisms underlies specific interactions of those compounds with major constituents of microbial membranes, in particular with (phospho)lipids. As some of the constituents of microbial membranes induce a number of physiological reactions, including inflammation in humans, agents that neutralise microbial membrane constituents might have a promising immunomodulatory role. In addition to being a target for drug discovery as a therapy or prevention of microbial infections, microbial membranes are also attractive for development of immunization strategies, e.g., bacterial membrane vesicle as potential candidates for vaccines development. In this context, the scope of this Special Issue focuses on membranes as a target for drug/vaccine development and agents strongly affecting membrane architecture in diverse pathogens.
Dr. Nermina Malanovic
Guest Editor
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Keywords
- antimicrobial peptides
- membrane-active compounds
- mode of action
- lipidoids
- vaccines
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