Special Issue "Membranes to Fight Drug-Resistant Microbes"

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Peptides".

Deadline for manuscript submissions: 30 June 2023 | Viewed by 199

Special Issue Editor

Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50/III, 8010 Graz, Austria
Interests: membrane-active compounds; antimicrobial peptides; anti-cancer peptides; lipid-peptide interactions; membrane-compound interaction; drug design

Special Issue Information

Dear Colleagues,

In the fight for finding possible ways to combat multidrug resistance, microbial membranes play a central role. Every microorganism is enveloped with a membrane, which gives them not only a unique character but protection that is essential for survival. The interruption of this fundamental barrier function leads to a rapid cell death and killing rate that is usually faster than the microbial growth rate. Such a non-specific mode of action is less likely to result in resistance and, amongst others, is effective on a variety of microbes, including bacteria, fungi, biofilms, and membrane-enveloped viruses. Compounds disrupting or acting on microbial membranes are generally termed as membrane-active and examples include antimicrobial peptides (AMPs), lipidoids, or many other small molecules, such as quaternary ammonium compounds. The mechanism behind the killing of microorganisms underlies specific interactions of those compounds with major constituents of microbial membranes, in particular with (phospho)lipids. As some of the constituents of microbial membranes induce a number of physiological reactions, including inflammation in humans, agents that neutralise microbial membrane constituents might have a promising immunomodulatory role. In addition to being a target for drug discovery as a therapy or prevention of microbial infections, microbial membranes are also attractive for development of immunization strategies, e.g., bacterial membrane vesicle as potential candidates for vaccines development. In this context, the scope of this Special Issue focuses on membranes as a target for drug/vaccine development and agents strongly affecting membrane architecture in diverse pathogens.

Dr. Nermina Malanovic
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • antimicrobial peptides
  • membrane-active compounds
  • mode of action
  • lipidoids
  • vaccines

Published Papers

This special issue is now open for submission.
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