New Inhibitors for Overcoming Antimicrobial Resistance
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: 31 March 2026 | Viewed by 2017
Special Issue Editors
Interests: resistance to antimicrobials; multidrug-resistant bacteria; efflux inhibitors; Staphylococcus aureus
Special Issue Information
Dear Colleagues,
Antimicrobial resistance (AMR) is a serious public health problem. Infections caused by multidrug-resistant strains often require prolonged patient hospitalization, combined antibiotic therapy, and, often, intensive care, placing a heavy burden on health systems. Several mechanisms contribute to AMR, such as efflux, reduced permeability, enzymatic degradation/modification of the antimicrobial, and target modification or protection. Biofilms are complex bacterial communities that also play a role in resilience to antibiotic therapy. Inhibitors of these mechanisms, e.g., efflux inhibitors, could be potential therapeutic agents when used in combination with antimicrobials, recovering their efficacy against MDR strains. This Special Issue will highlight recent developments in new AMR inhibitors from natural or synthetic sources, with a particular focus on efflux and related resistance mechanisms, such as reduced permeability and biofilms. We welcome new studies on new compounds or drugs already approved for use as potential inhibitors, aiming at their possible repurposing for use as antibiotic adjuvants. Reviews and studies characterizing efflux systems in bacteria, fungi, and protozoa, as well as the interplay between efflux and other resistance mechanisms, are also appreciated. Studies on the development of inhibitors of other mechanisms are also welcome.
Dr. Humberto Medeiros Barreto
Dr. Sofia Santos Costa
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antimicrobial resistance
- resistance mechanisms
- inhibitors
- enzymatic inhibitors
- efflux
- biofilms
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