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Antibiotics
Special Issues
Nanomaterials in Oral Health: Novel Antimicrobial Treatments in Dentistry
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Nanomaterials in Oral Health: Novel Antimicrobial Treatments in Dentistry

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Materials and Surfaces".

Deadline for manuscript submissions: closed (15 September 2025) | Viewed by 1363

Special Issue Editors

Dr. Liliana Burlibasa

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Guest Editor
Genetics Department, University of Bucharest, 1 Intr. Portocalilor, 060101 Bucharest, Romania
Interests: genotoxicity; nanomaterials; epigenetics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Serena Riela

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Guest Editor
Department of Chemistry, University of Catania, Via Andrea Doria, 6, 95125 Catania, Italy
Interests: organic chemistry; synthesis; drug delivery; coniugates; hallosyte nanotubes; carrier systems; nanomaterials; biocompatible materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The rise in antimicrobial resistance poses a significant challenge to oral healthcare, necessitating the development of innovative treatment strategies. Nanomaterials have emerged as promising agents in dentistry due to their unique physicochemical properties and potential to prevent biofilm formation and infections. This Special Issue focuses on the integration of nanotechnology into oral health, with a particular emphasis on the genotoxicity of nanomaterials.

We aim to explore the molecular and cellular mechanisms underlying the interaction between nanomaterials and human cells, their impact on oral microbiota, and their safety profiles. This Special Issue seeks to balance the promise of nanomaterials as effective antimicrobial agents with rigorous assessments of their potential risks.

In this Special Issue, original research articles and reviews are welcome. Topics of interest include, but are not limited to, the following:

  • Design and functionalization of nanomaterials for oral applications.
  • Molecular mechanisms of genotoxicity and cytotoxicity of nanomaterials.
  • Interactions of nanomaterials with oral microbiota.
  • Clinical applications and regulatory considerations.

We look forward to your contributions.

Dr. Liliana Burlibasa
Prof. Dr. Serena Riela
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • oral health
  • antimicrobial treatments
  • dentistry
  • genotoxicity

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Published Papers (1 paper)

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38 pages, 1839 KB  
Systematic Review
Nanofeatured Titanium Surfaces for Dental Implants: A Systematic Evaluation of Osseointegration
by Cristina Maria Șerbănescu, Viorel Ștefan Perieanu, Mădălina Adriana Malița, Mihai David, Mihai Burlibașa, Andrei Vorovenci, Camelia Ionescu, Radu Cătălin Costea, Oana Eftene, Ruxandra Stănescu, Mircea Popescu, Florentina Căminișteanu and Liliana Burlibașa
Antibiotics 2025, 14(12), 1191; https://doi.org/10.3390/antibiotics14121191 - 22 Nov 2025
Viewed by 894
Abstract
Background: Whether nanoengineered titanium surfaces confer superior implant stability beyond modern microrough controls remains uncertain. Methods: This systematic review followed PRISMA 2020 guidance: comprehensive multi-database searching with de-duplication; dual independent screening, full-text assessment, and standardized data extraction for predefined outcomes (implant stability quotient [...] Read more.
Background: Whether nanoengineered titanium surfaces confer superior implant stability beyond modern microrough controls remains uncertain. Methods: This systematic review followed PRISMA 2020 guidance: comprehensive multi-database searching with de-duplication; dual independent screening, full-text assessment, and standardized data extraction for predefined outcomes (implant stability quotient [ISQ], mechanical anchorage by removal/push-out/pull-out torque, and histologic bone-to-implant contact). Risk of bias was appraised with RoB 2 for randomized trials, ROBINS-I for non-randomized clinical studies, and CAMARADES (animal experimentation). The certainty of clinical evidence was summarized using GRADE. Results: Across animal models, nanoengineered surfaces consistently improved early osseointegration indices (higher removal torque and bone-to-implant contact at initial healing). In clinical comparative studies, nanoengineered implants showed modest, time-limited gains in early stability (ISQ) versus microrough titanium. By 3–6 months, between-group differences typically diminished, and no consistent advantages were demonstrated for survival or marginal bone outcomes at later follow-up. Methodologic heterogeneity (surface chemistries, timepoints, outcome definitions) and small clinical samples limited quantitative synthesis. Overall, risk-of-bias concerns ranged from some concerns to high in non-randomized studies; the certainty of clinical evidence was low. Conclusions: Nanofeatured titanium surfaces improve early osseointegration but do not demonstrate a consistent long-term advantage over modern microrough implants. Current evidence supports an early osseointegration benefit without clear long-term clinical advantage over contemporary microrough implants. Adequately powered, head-to-head trials with standardized stability endpoints and ≥12-month follow-up are needed to determine whether early gains translate into patient-important outcomes. Full article
(This article belongs to the Special Issue Nanomaterials in Oral Health: Novel Antimicrobial Treatments in Dentistry)
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