Current Updates on Antimicrobial Resistance in Pediatric Patients, 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1449

Special Issue Editors


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Guest Editor
Bristol Royal Hospital for Children, Bristol, UK
Interests: neonatal infections; paediatric antimicrobial stewardship (PAS)

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Guest Editor
Department of Pediatric and Adult Congenital Cardiology, University Hospital of Bordeaux, 33600 Bordeaux, France
Interests: echocardiography; pediatric cardiology; congenital heart disease; congenital cardiopathy in adults; artificial intelligence; automatic measurements
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Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) is currently one of the most important threats to public health worldwide and should be considered a top priority by all public health professionals and institutions.

The prevalence of multidrug-resistant organisms (MDROs) is significantly increasing and is associated with significant morbidity and mortality in affected patients. MDR bacteria are more resistant to treatment and are associated with more severe and prolonged disease, leading to longer hospitalization, with a 20% increase in the length of stay and deprivation outcomes, increasing mortality by up to 40% for hospital-acquired MDR infections.

Children are known to be the main beneficiaries of antimicrobial drugs compared to any other form of medication, as they are frequent subjects of infections of various etiologies, from the most common urinary tract infections to the less common meningitis. The most important cause of modern antibiotic resistance is the inappropriate use of antibiotics.

An insufficient knowledge of the pathogens associated with different infections, along with the pharmacokinetic and pharmacodynamic properties of specific classes of antibiotics, underlies bacterial resistance. These characteristics have a significant impact on the drug selection process, on the correct dosage and on the duration of treatment.

In addition, antibiotics are still frequently prescribed for misdiagnosed conditions such as viral infections, especially in ambulatory care.

This Special Issue plans to provide an overview of the most recent advances in the field of antimicrobial resistance in pediatric patients.

Potential topics include, but are not limited to, the following:

  • Antimicrobial resistance;
  • Inappropriate antibiotic use in pediatrics;
  • Public health;
  • Adverse effects of antibiotics;
  • Multidrug-resistant bacteria;
  • Future perspectives on antimicrobial resistance;
  • Role of antimicrobial resistance in pediatric patients.

Dr. Stefania Vergnano
Dr. Corina Maria Vasile
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • inappropriate antibiotic use in pediatrics
  • public health
  • adverse effects of antibiotics
  • multidrug-resistant bacteria
  • future perspectives on antimicrobial resistance
  • role of antimicrobial resistance in pediatric patients

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Published Papers (1 paper)

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Research

17 pages, 2609 KiB  
Article
Assessment of Antibiotic Resistance in Pediatric Infections: A Romanian Case Study on Pathogen Prevalence and Effective Treatments
by Maria Madalina Singer, Renata Maria Văruț, Cristina Popescu, Kristina Radivojevic, Luciana Teodora Rotaru, Damian Roni Octavian, Banicioiu Mihai-Covei, Mihaela Popescu, Oancea Andreea Irina, Dragos Oancea, Alin Iulian Silviu Popescu and Cristina Elena Singer
Antibiotics 2024, 13(9), 879; https://doi.org/10.3390/antibiotics13090879 - 13 Sep 2024
Viewed by 1011
Abstract
Antibiotic misuse in Romania has exacerbated the issue of antibiotic resistance, as patients often use antibiotics without proper medical consultation. This study aimed to assess the resistance of prevalent bacteria to different antibiotics. In this observational study conducted over six months, we analyzed [...] Read more.
Antibiotic misuse in Romania has exacerbated the issue of antibiotic resistance, as patients often use antibiotics without proper medical consultation. This study aimed to assess the resistance of prevalent bacteria to different antibiotics. In this observational study conducted over six months, we analyzed 31 pediatric patients aged from 12 days to 13 years using the disk diffusion method. We identified 31 bacterial isolates, including 8 Gram-negative and 8 Gram-positive strains, with the most common being Pseudomonas aeruginosa, Escherichia coli, Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, Streptococcus species, and Elizabethkingia meningoseptica. Our findings revealed that the most effective antibiotics were linezolid, ertapenem, and teicoplanin. In contrast, nearly all tested bacteria exhibited resistance to penicillin, followed by oxacillin and ampicillin. Resistance to cephalosporins varied with generation, showing higher resistance to lower-generation cephalosporins. The study highlights significant antibiotic resistance among common bacterial pathogens in Romanian pediatric patients, emphasizing the urgent need for controlled antibiotic use and alternative treatment strategies to combat this growing issue. Effective antibiotics such as linezolid and ertapenem offer potential solutions, whereas reliance on penicillin and lower-generation cephalosporins is increasingly futile. Full article
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