Mechanisms of Microbial Biofilm Resistance and New Methods for Biofilm Control
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiofilm Strategies".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 1097
Special Issue Editor
Special Issue Information
Dear Colleagues,
Biofilm growth represents a key microbial strategy in terms of colonization, pathogenicity, and resistance, allowing microorganisms to persist both in the environment and within a host during infection. Within biofilms, microbial cells exhibit peculiar features that differ from planktonic ones, and special phenotypes are induced that can endure antimicrobial pressure. Indeed, bacterial cells growing in biofilms can be 10 to 1000 times more resistant to antibiotics, and this constitutes one of the main reasons for the lack of eradication of infections. Moreover, biofilms favor DNA exchange between cells, increasing the spread of antimicrobial resistance.
The development of molecular and microscopy techniques has provided novel and valuable information about biofilm formation, architecture, and responses to antibiotic treatment; still, a number of details remain to be elucidated regarding the regulatory pathways controlling the physiology of sessile cultures. Furthermore, there is an urgent need for novel antibiofilm approaches and/or molecules, to achieve their eradication and infection clearance.
This Special Issue will focus on novel advances in the study of biofilm lifestyles, the features characterizing sessile cells, their resistance to antibiotics, and the identification of new compounds endowed with antibiofilm activity.
Dr. Gianmarco Mangiaterra
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- quorum sensing
- chronic infections
- antibiotic resistance
- persistence
- efflux pumps
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