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Animals
Special Issues
Veterinary Antimicrobial Resistance Mechanisms and New Control Strategies
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Veterinary Antimicrobial Resistance Mechanisms and New Control Strategies

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 3395

Special Issue Editors

Dr. Wanjiang Zhang

E-Mail Website
Guest Editor
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China
Interests: generation; transmission mechanism; prevention and control techniques of bacterial resistance in animals
Special Issues, Collections and Topics in MDPI journals
Dr. Yang Yu

E-Mail Website
Guest Editor
College of Veterinary Medicine SCAU, South China Agricultural University, Guangzhou, China
Interests: antimicrobial resistance (AMR); pharmacokinetics and pharmacodynamics Modeling (PK/PD); combination Therapy

Special Issue Information

Dear Colleagues, 

The emergence and dissemination of antimicrobial resistance have become a global threat to public health systems. The World Health Organization (WHO) has identified antimicrobial resistance as one of the top three major threats to public health. Antimicrobial resistance in animals not only has a great impact on animal health but is also closely associated with resistant infections in humans. In recent years, the increasing incidence of multi-drug resistance and even pan-drug resistance in animals has posed a serious threat to public health and food safety. The aim of this Special Issue is to publish original research papers or reviews concerning mechanisms of antimicrobial resistance in important pathogens or commensal bacteria of animal origin, and new strategies to prevent and control bacterial resistance in animals.

Dr. Wanjiang Zhang
Dr. Yang Yu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • mechanisms of resistance
  • bacteria of animal origin
  • experimental therapeutics
  • new strategies/techniques to prevent bacterial resistance

Published Papers (2 papers)

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Research

22 pages, 6751 KiB  
Article
Analysis of Gut Microbial Communities and Resistance Genes in Pigs and Chickens in Central China
by Yapei Rui and Gang Qiu
Animals 2022, 12(23), 3404; https://doi.org/10.3390/ani12233404 - 2 Dec 2022
Cited by 4 | Viewed by 1327
Abstract
Background: Basic data concerning the gut microbiota of the main animal husbandry breeds (pigs and chickens) are scarce in China. The dynamics of gut microbiota (pigs and chickens) in China and antibiotic resistance genes carried by microorganisms in the natural environment are unknown. [...] Read more.
Background: Basic data concerning the gut microbiota of the main animal husbandry breeds (pigs and chickens) are scarce in China. The dynamics of gut microbiota (pigs and chickens) in China and antibiotic resistance genes carried by microorganisms in the natural environment are unknown. Methods: Free range and factory-farmed Gushi chickens and Huainan pigs were divided into eight groups. Faecal samples were collected from each group, and the metagenomic sequencing method was used to detect each group of samples. Results: The resistance genes showed the following trend, from high to low relative abundance: tetW was the highest, followed by tetW/N/W, then lnuA; and others from high to low were mdtB, lnuC, ANT6-la, ErmB, mdtC, ErmQ, tetBP, vatE, evgS, acrB, cpxA, mefA, Escherichia coli-ampC, tetL, yojl, AcrF and mdtA. All groups administered enrofloxacin and oregano oil did not develop a drug-resistant phenotype during the 5-day treatment period, as grouped in this trial. In 2022, after Announcement No. 194 of the Ministry of Agriculture and Rural Affairs in China, the antimicrobial resistance (AMR) trend declined, but it did not fundamentally change, presumably due to the impact of environmental pollution caused by the long-term use of antimicrobials. Full article
(This article belongs to the Special Issue Veterinary Antimicrobial Resistance Mechanisms and New Control Strategies)
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15 pages, 1584 KiB  
Article
Antimicrobial Resistance and Transconjugants Characteristics of sul3 Positive Escherichia coli Isolated from Animals in Nanning, Guangxi Province
by Qinmei Li, Zheng Li, Yuhan Wang, Yunru Chen, Junying Sun, Yunqiao Yang and Hongbin Si
Animals 2022, 12(8), 976; https://doi.org/10.3390/ani12080976 - 10 Apr 2022
Cited by 3 | Viewed by 1723
Abstract
Sulfonamides are the second most popular antibiotic in many countries, which leads to the widespread emergence of sulfonamides resistance. sul3 is a more recent version of the gene associated with sulfonamide resistance, whose research is relatively little. In order to comprehend the prevalence [...] Read more.
Sulfonamides are the second most popular antibiotic in many countries, which leads to the widespread emergence of sulfonamides resistance. sul3 is a more recent version of the gene associated with sulfonamide resistance, whose research is relatively little. In order to comprehend the prevalence of sul3 positive E. coli from animals in Nanning, a total of 146 strains of E. coli were identified from some farms and pet hospitals from 2015 to 2017. The drug resistance and prevalence of sul3 E. coli were analyzed by polymerase chain reaction (PCR) identification, multi-site sequence typing (MLST), drug sensitivity test, and drug resistance gene detection, and then the plasmid containing sul3 was conjugated with the recipient strain (C600). The effect of sul3 plasmid on the recipient was analyzed by stability, drug resistance, and competitive test. In this study, forty-six sul3 positive E. coli strains were separated. A total of 12 ST types were observed, and 1 of those was a previously unknown type. The ST350 is the most numerous type. All isolates were multidrug-resistant E. coli, with high resistant rates to penicillin, ceftriaxone sodium, streptomycin, tetracycline, ciprofloxacin, gatifloxacin, and chloramphenicol (100%, 73.9%, 82.6%, 100%, 80.4%, 71.7%, and 97.8%, respectively). They had at least three antibiotic resistance genes (ARGs) in addition to sul3. The plasmids transferred from three sul3-positive isolates to C600, most of which brought seven antimicrobial resistance (AMR) and increased ARGs to C600. The transferred sul3 gene and the plasmid carrying sul3 could be stably inherited in the recipient bacteria for at least 20 days. These plasmids had no effect on the growth of the recipient bacteria but greatly reduced the competitiveness of the strain at least 60 times in vitro. In Nanning, these sul3-positive E. coli had such strong AMR, and the plasmid carrying sul3 had the ability to transfer multiple resistance genes that long-term monitoring was necessary. Since the transferred plasmid would greatly reduce the competitiveness of the strain in vitro, we could consider limiting the spread of drug-resistant isolates in this respect. Full article
(This article belongs to the Special Issue Veterinary Antimicrobial Resistance Mechanisms and New Control Strategies)
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