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5.2
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Journals
Animals
Special Issues
Extracellular Vesicles in Animal Reproduction
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Extracellular Vesicles in Animal Reproduction

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Reproduction".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 1304

Special Issue Editor

Prof. Dr. Anna Lange-Consiglio

E-Mail Website
Guest Editor
Laboratory of Reproduction, Department of Veterinary Medicine and Animal Science, University of Milan, Via dell'Università 6, 26900 Lodi, Italy
Interests: biologia cellulare; medicina rigenerativa; biotecnologie riproduttive
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Many recent reviews have highlighted the role that EVs play in the paracrine communication in oogenesis, oocyte maturation, fertilization, embryo–maternal cross-talk in the oviduct, and embryo implantation. Some of the roles include the following: follicular EVs secreted by granulosa cells promote oocyte maturation and increase the expression of key genes; EVs from male reproductive tracts contribute to the complex pool of EVs that are able to assist sperm maturation and influence the physiology of female reproductive tract cells to support reproductive success; and the success of pregnancy requires a molecular dialogue between the embryo and the female reproductive tract that starts at the oviduct and continues until embryo development, implantation, and the formation of the placenta.

The aim of Special Issue is to collect new data on paracrine communication mechanisms through EVs in reproduction. Furthermore, data on the morphological and molecular responses to environmental stressors on gametes and preimplantation embryos will contribute to this Special Issue.

Original research articles, reviews, short papers, mini reviews, communications, and perspective regarding all processes of reproductive biology are well welcome.

We look forward to receiving your contributions.

Prof. Dr. Anna Lange-Consiglio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproduction
  • gametes
  • embryos
  • extracellular vesicles
  • microRNA
  • biomarkers
  • fertility

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Published Papers (1 paper)

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Research

19 pages, 2164 KB  
Article
LPS-Stressed Bovine Endometrial Cells upon Morulae in a Transwell Model of Embryo—Maternal Talk
by Anna Lange-Consiglio, Giulia Gaspari, Paola Gagni, Giampaolo Bosi, Pietro Riccaboni and Fausto Cremonesi
Animals 2026, 16(1), 38; https://doi.org/10.3390/ani16010038 - 23 Dec 2025
Viewed by 804
Abstract
During the preimplantation period, the nutrition of the embryo is dependent on luminal secretions of the uterus, which can be modified by the health status of the animal. The aim of this study was to mimic the paracrine communication between healthy or LPS-stressed [...] Read more.
During the preimplantation period, the nutrition of the embryo is dependent on luminal secretions of the uterus, which can be modified by the health status of the animal. The aim of this study was to mimic the paracrine communication between healthy or LPS-stressed epithelial endometrial cells (EECs) and embryos using aa transwell plate. The rate of in vitro embryo production, size, and concentration of extracellular vesicles (EVs), and level of secretion of Galectin-9 (Gal-9) and leukaemia inhibitory factor (LIF) were detected. Embryos were produced with an established protocol of oocyte in vitro maturation (IVM), in vitro fertilization (IVF), and in vitro embryo culture (IVC). On day 55 of IVC, one hour before the transfer of morulae in the basolateral compartment of the transwell, EECs were treated with 10 ng/mL of LPS, and IVC was continued until the eleventh day. Extracellular vesicles (EVs) were obtained from IVC medium by ultracentrifugation. Levels of Gal-9 and LIF were evaluated by ELISA. On day 7, the results did not show statistically different blastocyst rates between EECs+Embryo and EECs+LPS+Embryo (34.94 ± 1.95% and 33.06 ± 3.08%, respectively). On day 11, the rate of hatched blastocysts was 23.03 ± 3.18% in EECs+Embryo, while in EECs+LPS+Embryo, no hatching was observed. Nanosight revealed higher values in EV size and concentration in EECs+LPS+Embryo medium compared to EECs+Embryo (p < 0.05). In LPS-treated samples, there was a significant decrease in Gal-9 levels and a significant increase in LIF secretions compared with non-non-LPS-treated samples (p < 0.05). These results highlight how bidirectional secretions between EECs and embryos, crucial for embryo development, can be affected by endometritis. Full article
(This article belongs to the Special Issue Extracellular Vesicles in Animal Reproduction)
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