Mesenchymal Stromal Cells and Platelet Rich Plasma: Their Regenerative Potential in Reproductive Disorders in Farm Animals
A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Reproduction".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 8054
Special Issue Editor
Interests: biologia cellulare; medicina rigenerativa; biotecnologie riproduttive
Special Issue Information
Dear Colleagues,
Chronic endometritis is an inflammation in the inner layer of uterine mucosa, with or without an infectious process that could develop because of reduced intrinsic uterine defenses, leading to the uncontrolled proliferation of resident microflora causing persistent inflammation. Endometriosis is another chronic degenerative condition of multifactorial origin. The main consequence of endometritis is a uterine environment that is hostile for embryo survival and implantation, causing embryo death and abortion, so this pathology is one of the most frequent causes of infertility. Despite the wide range of therapies proposed to date, no effective treatments have been able to renew the injured tissue or to stop this process.
The communication between uterus and conceptus, essential for adhesion and implantation, occurs via paracrine signaling. Defects in the endometrial tissue could hinder this passage of information and lead to reduced fertility.
An alternative therapy for uterine disease could be represented by the use of stem cell or platelet-rich plasma, which are both able to provide growth factors, chemokines, cytokines, and extra-cellular vesicles essential to restore fetal-maternal communication and embryo implantation. This Special Issue collects the novel therapeutic approaches based on endometrium regeneration and restoration of paracrine fetal-maternal talk by the use of these new products in animal species.
This Research Topic gathers original research, reviews (mini review, systematic review, focused review), brief research reports, and case reports (case reports must describe a novel finding related to mesenchymal stromal cells or platelet-rich plasma use in more than one subject). Clinical studies and laboratory original research will both be evaluated.
Dr. Anna Lange-Consiglio
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- endometritis
- endometrosis
- fetal–maternal communication
- embryo
- regenerative medicine
- stem cells
- conditioned medium
- extra-cellular vesicles
- platelet-rich plasma
- animals
