Special Issue "New Insights into Animal Spermatogenesis"

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Reproduction".

Deadline for manuscript submissions: 28 February 2021.

Special Issue Editors

Dr. Alessandra Santillo
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Guest Editor
Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università della Campania L. Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy
Interests: spermatogenesis; steroidogenesis; excitatory amino acid; sex hormones; endocrine and exocrine secretions
Prof. Maria Maddalena Di Fiore
Website
Guest Editor
Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università della Campania L. Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy
Interests: Reproduction; Testis; Sex hormones; Sex hormone receptors

Special Issue Information

Dear Colleagues,

In vertebrates, spermatogenesis is a highly complex and coordinated process leading to the formation of the mature gametes, the spermatozoa. The whole process is regulated by gonadotropins, steroid hormones and a complex network of autocrine and paracrine factors, whose role is mediated by the activation/inhibition of several intracellular signaling pathways. Furthermore, a cell type- and stage-specific induction or repression of the specific gene expression underlies the regulation of spermatogenesis.

Sex steroid hormones and their receptors play a crucial role in the testis, regulating the reproductive processes through either the promotion of spermatogenesis and spermiogenesis or the development and maintenance of secondary sex characters. The synthesis of sex steroids is a conserved process in vertebrates. Studies carried out in invertebrates and in low vertebrates have proven useful in understanding the evolutionary aspects of the spermatogenesis.

This Special Issue aims to widen the knowledge on spermatogenesis and spermiogenesis from a comparative point of view. Therefore, we invite high-quality and original research or review papers that address new insights on this topic, including the molecular mechanisms underlying the differentiation/maturation of germ cells. The understanding of the multitude of proteins and factors that regulate the dynamic of this process is undoubtedly of crucial importance.

Dr. Alessandra Santillo
Prof. Maria Maddalena Di Fiore
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • spermatogenesis
  • steroidogenesis
  • testis
  • sex hormones
  • sex hormone receptors
  • germ cell differentiation
  • invertebrates
  • vertebrates

Published Papers (2 papers)

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Research

Open AccessArticle
Preliminary Investigation on the Ameliorative Role Exerted by D-Aspartic Acid in Counteracting Ethane Dimethane Sulfonate (EDS) Toxicity in the Rat Testis
Animals 2021, 11(1), 133; https://doi.org/10.3390/ani11010133 - 08 Jan 2021
Abstract
Herein is reported the first evidence of the protective role of D-aspartic acid (D-Asp) in preventing the toxic effect exerted by the alkylating agent ethane dimethane sulfonate (EDS) in the rat testis. We confirmed that EDS treatment specifically destroyed Leydig cells (LC), resulting [...] Read more.
Herein is reported the first evidence of the protective role of D-aspartic acid (D-Asp) in preventing the toxic effect exerted by the alkylating agent ethane dimethane sulfonate (EDS) in the rat testis. We confirmed that EDS treatment specifically destroyed Leydig cells (LC), resulting in the drastic decrease of the serum testosterone level and producing morphological changes in the germinal tubules, i.e., altered organization of the epithelium, loss of cell contacts and the consequent presence of empty spaces between them, and a reduce number of spermatozoa. Moreover, an increase of TUNEL-positive germ cells, other than alteration in the protein level and localization of two LC “markers”, StAR and PREP, were observed. Interestingly, results obtained from rats pre-treated with D-Asp for 15 days before EDS-injection showed that all the considered parameters were quite normal. To explore the probable mechanism(s) involved in the protection exerted by D-Asp, we considered the increased oxidative stress induced by EDS and the D-Asp antioxidant effects. Thiobarbiturc acid-reactive species (TBARS) levels increased following EDS-injection, while no change was observed in the D-Asp + EDS treated rats. Our results showed that D-Asp may be used as a strategy to mitigate the toxic effects exerted by environmental pollutants, as endocrine disrupters, in order to preserve the reproductive function. Full article
(This article belongs to the Special Issue New Insights into Animal Spermatogenesis)
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Open AccessFeature PaperArticle
E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice
Animals 2020, 10(9), 1691; https://doi.org/10.3390/ani10091691 - 18 Sep 2020
Abstract
In the mammalian testes, Sertoli cells are the only somatic cells in the seminiferous tubules that provide structural, nutritional and regulatory support for developing spermatogenic cells. Sertoli cells only proliferate during the fetal and neonatal periods and enter a quiescent state after puberty. [...] Read more.
In the mammalian testes, Sertoli cells are the only somatic cells in the seminiferous tubules that provide structural, nutritional and regulatory support for developing spermatogenic cells. Sertoli cells only proliferate during the fetal and neonatal periods and enter a quiescent state after puberty. Functional evidences suggest that the size of Sertoli cell population determines sperm production and fertility. However, factors that direct Sertoli cell proliferation and maturation are not fully understood. Transcription factor E4F1 is a multifunctional protein that serves essential roles in cell fate decisions and because it interacts with pRB, a master regulator of Sertoli cell function, we hypothesized that E4F1 may have a functional role in Sertoli cells. E4f1 mRNA was present in murine testis and immunohistochemical staining confirmed that E4F1 was enriched in mature Sertoli cells. We generated a conditional knockout mouse model using Amh-cre and E4f1flox/flox lines to study E4F1 fucntion in Sertoli cells and the results showed that E4f1 deletion caused a significant reduction in testis size and fertility. Further analyses revealed that meiosis progression and spermiogenesis were normal, however, Sertoli cell proliferation was impaired and germ cell apoptosis was elevated in the testis of E4f1 conditional knockout mice. On the basis of these findings, we concluded that E4F1 was expressed in murine Sertoli cells and served important functions in regulating Sertoli cell proliferation and fertility. Full article
(This article belongs to the Special Issue New Insights into Animal Spermatogenesis)
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