Diseases of the Small and Large Intestine, Liver and Pancreas in Small Animals: Second Edition
A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".
Deadline for manuscript submissions: 20 December 2024 | Viewed by 2505
Special Issue Editors
Interests: small animal oncology and gastroenterology
Special Issues, Collections and Topics in MDPI journals
Interests: veterinary clinical pathology; small animal internal medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to present you with the second edition of the Animals Special Issue on “Diseases of the Small and Large Intestine, Liver and Pancreas in Small Animals.”
After the first edition collected amazing manuscripts from eminent international authors in the field, we wish to continue to contribute to the sharing of scientific evidence in small animal gastroenterology.
This Special Issue welcomes a wide range of research articles related to small animal gastroenterology. We welcome papers from any field related to diseases of the intestine, liver, and pancreas in small animals, such as clinical and clinicopathological markers, interactions between the diet, microbiota, and gut, metabolomics, ultrasonography, and advanced imaging, interventional radiology, novel treatments, and comparative pathologies. Intestinal, pancreatic, and hepatic diseases present a daily challenge for clinicians worldwide; small animal gastroenterology is still one of the fastest-growing research fields with new diagnostic and prognostic markers and therapeutic strategies for various intestinal, pancreatic, and liver diseases.
Dr. Alessio Pierini
Dr. Eleonora Gori
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- small animal gastroenterology
- intestine
- liver
- pancreas
- microbiota
- gut
- clinicopathological markers
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Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Fecal bile acids in canine chronic hepatobiliary disease: results in 46 dogs
Authors: Verena Habermaass; Francesco Bartoli; Eleonora Gori; Rebecca Dini; Aurora Cogozzo; Caterina Puccinelli; Alessio Pierini; Veronica Marchetti
Affiliation: Department of Veterinary Sciences, Veterinary Teaching Hospital “Mario Modenato”, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, Italy
Abstract: Both fecal and serum bile acids (BAs) concentrations are known to be altered in human patients with chronic hepatobiliary diseases (CHBDs), especially with biliary involvement (BTD). Scarce literature is available regarding potential fecal BAs modifications during canine CHBDs. The present study aimed to evaluate fecal BAs in dogs with CHBDs according to different clinical and clinicopathological variables. Forty-six dogs were enrolled. Canine feces were analyzed by HPLC. Cholic Acid (CA), Chenodeoxycholic Acid (CDCA), Ursodeoxycholic Acid (UDCA), Deoxycholic Acid (DCA), Lithocholic Acid (LCA), Deoxycholic Acid (DCA) were measured, Total Primary (CA+CDCA) and Secondary BAs (UDCA+DCA+LCA), Primary/Secondary (P/S) ratio were calculated. Primary BAs, CA, CDCA, P/S ratio and Total BAs were significatively increased in BTD dogs (n=18) compared to non-BTD (n=28). Gastrointestinal clinical signs were significantly more prevalent in BTD dogs compared to non-BTD dogs, supporting the hypothesis of some pathological mechanisms assimilable to bile acid diarrhea (BAD). Primary BAs were significantly reduced in dogs with more relevant serum Alanine-Aminotransferase increase. Our results could reflect imbalances of the Liver-Gut axis in CHBD dogs. Further studies involving gut microbiome and metabolomic assessment are needed to better understand possible clinical implications of BAs metabolism disruption and their potential role in canine CHBD.
Title: Allogenic Adipose Derived Mesenchymal Stem Cell Infusion for the Management of Acute-Onset Pancreatitis in Dogs
Authors: Harry Cridge; Valerie Johnson
Affiliation: Department of Small Animal Clinical Sciences, Michigan State University College of Veterinary Medicine, East Lansing, MI 28824, USA.
Abstract: Mesenchymal stem cells (MSCs) have significant anti-inflammatory properties and are beneficial in rodent models of pancreatitis. The safety and efficacy of MSCs is unknown in dogs with acute pancreatitis (AP). Dogs with AP treated with MSCs (n=4) were identified from the case logs of an academic hospital. Serum Spec cPL and C-reactive protein (CRP) concentrations were measured on day of MSC administration and 2 days later. Clinical severity, via MCAI, was also calculated. Two dogs received MSCs shortly after AP diagnosis, while the remaining dogs received MSCs due to clinically refractory disease. Changes in Spec cPL, CRP, and MCAI in the MSC-treated dogs were compared to a control population (n = 7) receiving standard of care treatment for AP. No significant differences were noted between the populations for change in Spec cPL (P = .79), CRP (P = .67), or MCAI (P = .91). However, subjective clinical improvement was noted within 24 hours of MSC infusion in the 2 dogs with previously refractory disease. MSC infusions appear safe in the management of AP in dogs and may be considered in refractory disease. Larger randomized controlled clinical trials are needed to evaluate the efficacy of MSC infusions in dogs with AP.