Special Issue "Decoding the Genetics of Bovine Mastitis"
Deadline for manuscript submissions: closed (15 August 2022) | Viewed by 2443
Interests: bovine mastitis; gene regulation network construction; gene expression; epigenetic
Interests: milk fat traits; gene regulation network construction; gene expression; epigenetic; circRNA; lincRNA miRNA; mRNA
Special Issues, Collections and Topics in MDPI journals
The tens of thousands of years of wild animal domestication, natural selection, and artificial selection have seen the emergence of the existing livestock species we have all over the world today. With the improvement of genetic theories, conventional animal breeding techniques have developed from general phenotypic selection to the use of genetic methods to estimate breeding values. Moreover, great contributions have been made to the genetic improvement of livestock in the past few decades too. Since the 1980s, the appearance of various molecular genetic markers and the development of modern biotechnology provided new methods for improving animal genetic breeding. The integration of various omics information, such as DNA, RNA, protein, epigenetic regulation, brings new opportunities for the mining of important economic traits of animals and the analysis of molecular genetic mechanisms. Functional genes can be mined and screened from different levels (including circRNA, lincRNA miRNA, and mRNA) and perspectives by obtaining information on the genome, transcriptome, proteome, epigenome, and metagenome. In this way, gene networks and regulatory pathways can be studied more efficiently, thus laying a solid foundation for analyzing the mechanism of functional genes.
Mastitis in dairy cow causes significant economic losses through the decreased production and milk quality. The compromised milk also poses a health hazard if it is consumed. Pathogenic microbial infection is the main cause of mastitis. Pathogens can colonize and multiply in the mammary gland, and can enter and persist in host cells. Most antibiotics cannot enter cells or may be ineffective if their cellular concentration is too low. Pathogens can also develop resistance to antibiotics. Residual antibiotics in milk present significant food safety problems for human health. Therefore, non-antibiotic methods for the prevention and treatment of bovine mastitis have attracted great interest. This research topic will focus on applying the advances to explore gene regulation and its molecular mechanism in bovine mastitis.
Prof. Dr. Zhangping Yang
Prof. Dr. Zhi Chen
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- bovine mastitis
- gene regulation network construction
- gene expression