Production, Breeding and Disease Management of Plateau Animals—Second Edition

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal System and Management".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 712

Special Issue Editors


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Guest Editor
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
Interests: microbiota; nutrition; yaks; poultry; disease management; probiotics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
College of Animal Science, Tibet Agriculture and Animal Husbandry University, Nyingchi 860000, China
Interests: gut microbiota; animal genomics; Tibetan pigs; Tibetan chickens; genetic breeding; healthy farming; plateau livestock
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to advancing the science of animal husbandry in high-altitude plateau regions. It will focus on the unique challenges and opportunities presented by these extreme environments, which are characterized by hypoxia, low temperatures, and strong UV radiation. The scope encompasses a wide range of topics, including innovative production systems, genetic improvement and breeding strategies for resilience, nutritional management for native forages, and the epidemiology, diagnosis, and control of endemic diseases affecting livestock and other plateau-adapted animals.

The purpose of this Special Issue is to collate high-quality research that enhances the sustainability, productivity, and welfare of plateau animal agriculture. It aims to provide a platform for sharing novel insights that bridge the gap between traditional practices and modern scientific innovation.

This Special Issue will effectively supplement the existing literature by consolidating fragmented research into a comprehensive resource that addresses the interconnected nature of production, breeding, and health in these unique ecosystems. It will specifically highlight adaptive mechanisms to environmental stressors and explore integrated management approaches, thereby offering valuable knowledge for researchers, veterinarians, and policymakers dedicated to the sustainable development of plateau pastoralism in an era of global change. We invite original research and review articles that contribute to this vital field.

Prof. Dr. Jiakui Li
Prof. Dr. Peng Shang
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • high-altitude plateau
  • yaks
  • native forages
  • genetics and breeding
  • epidemiology

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Published Papers (1 paper)

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Research

19 pages, 9552 KB  
Article
Characterization and Genomic Analysis of Pasteurella multocida NQ01 Isolated from Yak in China
by Kewei Li, Haofang Yuan, Chao Jin, Muhammad Farhan Rahim, Xire Luosong, Tianwu An and Jiakui Li
Animals 2025, 15(23), 3462; https://doi.org/10.3390/ani15233462 - 1 Dec 2025
Cited by 2 | Viewed by 534
Abstract
Hemorrhagic septicemia (HS) is a fulminant bovine disease across Asia and Africa, yet Pasteurella multocida (P. multocida) isolated from yak is poorly reported. We isolated strain NQ01 from a fatal HS case in Xizang, China and identified it as P. multocida [...] Read more.
Hemorrhagic septicemia (HS) is a fulminant bovine disease across Asia and Africa, yet Pasteurella multocida (P. multocida) isolated from yak is poorly reported. We isolated strain NQ01 from a fatal HS case in Xizang, China and identified it as P. multocida B:2 by morphology, Gram stain, and PCR (kmt1+, bcbD+, LPS L2). NQO1 formed smooth, non-hemolytic colonies. After Gram staining, the cells appeared as red rods with bipolar staining. Antimicrobial testing showed broad susceptibility to β-lactams, aminoglycosides, tetracyclines, fluoroquinolones, midecamycin, florfenicol, polymyxin, and vancomycin, with resistance to metronidazole, trimethoprim sulfamethoxazole, and clindamycin. Streptomycin and ofloxacin had intermediate activity. In mice, the intraperitoneal and intranasal LD50 values were 40.64 CFU/mL and 9.53 × 106 CFU/mL, respectively. The intranasal fatal cases were characterized by bacteremia with multifocal disseminated intravascular coagulation involving lung, liver, and spleen. The complete genome comprises a single 2.33 Mb chromosome (40.47% GC, 2115 CDS, no plasmids) with only one resistance gene (Eco_EFTu_PLV) and 28 virulence genes spanning adhesion (tadA, rcpA, ppdD, pilB, tuf/tufA, htpB, PM_RS00430, PM_RS00425, PM_RS08640), immune modulation (lpxB/C/D, msbB, manB, rfaE/F, gmhA/lpcA, kdsA, pgi, wecA, galE, bexD’, ABZJ_RS06285, ABD1_RS00310), and nutritional/metabolic factor (hgbA, hemR, hemN), plus a YadA-like factor. Phylogenetically, NQ01 clusters with regional B:2 bovine/yak isolates. Collectively, these data define NQ01 as a highly virulent, low-resistance yak isolate and a practical model for natural-route HS pathogenesis and targeted control in high-altitude pastoral settings yaks. Full article
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