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Animals
Special Issues
Application of Regenerative Medicine in the Field of Veterinary Medicine
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Application of Regenerative Medicine in the Field of Veterinary Medicine

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 4038

Special Issue Editors

Dr. Young-Sam Kwon

E-Mail Website
Guest Editor
College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea
Interests: mesenchymal stem cells; exosome; dog; cat; inflammation; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Prof. Min-Soo Seo

E-Mail Website
Guest Editor
College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea
Interests: mesenchymal stem cells; exosome; dog; cat; stem cell differentiation; exosome isolation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In veterinary medicine, regenerative medicine can be broadly defined as finding methods to heal, replace, and regenerate severely damaged tissues and organs, as well as pursuing methods to treat chronic diseases in animals. These methods include stem cell therapy, PRP therapy, tissue engineering, and gene therapy. Recently, research on therapies utilizing stem cell-derived exosomes has been growing in prominence. Regenerative medicine offers various advantages in veterinary care, aiding in the treatment of conditions such as osteoarthritis, tendon injuries, ligament tears, etc. Additionally, trials concerning potential treatments for systemic diseases like diabetes, hepatitis, atopic dermatitis, and dementia are ongoing and necessary. In this context, ongoing research into alternative therapies for tissue damage and the treatment of disease in animals is essential.

In this Special Issue, we aim to publish original research articles and reviews that are specifically focused on tissue regeneration, including studies on the effects of stem cell therapy, platelet-rich plasma (PRP) therapy, tissue engineering, gene therapy, and exosome therapy. In doing so, we hope to take a step closer to the development of novel alternative treatments for the management of chronic diseases in animals. We look forward to receiving your contributions.

Dr. Young-Sam Kwon
Prof. Min-Soo Seo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative medicine
  • stem cells
  • platelet-rich plasma
  • tissue engineering
  • gene therapy
  • exosome therapy

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

15 pages, 6640 KiB  
Article
Evaluation of the Effects of Autologous Leukocyte- and Platelet-Rich Fibrin Membranes for Treating Chronic Wounds: A Prospective Study
by Federica Aragosa, Gerardo Fatone, Chiara Caterino, Stefano Cavalli, Alfonso Piscitelli, Rosario Vallefuoco, Francesco Lamagna and Giovanni Della Valle
Animals 2025, 15(1), 112; https://doi.org/10.3390/ani15010112 - 6 Jan 2025
Viewed by 295
Abstract
(1) Background: The aim of this prospective study was to evaluate the efficacy of topical application of leukocyte- and platelet-rich fibrin (L-PRF) membranes for treating chronic cutaneous wounds in dogs. (2) Methods: Chronic wounds unresponsive to conventional treatments were assessed on digital photographs [...] Read more.
(1) Background: The aim of this prospective study was to evaluate the efficacy of topical application of leukocyte- and platelet-rich fibrin (L-PRF) membranes for treating chronic cutaneous wounds in dogs. (2) Methods: Chronic wounds unresponsive to conventional treatments were assessed on digital photographs and classified using the Bates-Jensen Wound Assessment Tool (BWAT). Each lesion was treated with L-PRF membranes. Epithelialization, granulation tissue formation, wound healing rate, and contraction were statistically analyzed during follow-up. (3) Results: All but one of the cases were treated with a single application of L-PRF for a median of 30 days after onset. All wounds healed after a median of 22 days. The BWAT score, total wound area, and granulation tissue decreased significantly over time while wound contraction increased. The most significant reduction in the total wound area was observed within the first 3 weeks after treatment. None of the dogs required the administration of antibiotics. (4) Conclusions: L-PRF membrane promoted the wound healing process in dogs and is a valuable and cost-effective tool for treating chronic wounds, thereby reducing the need for antibiotics administration. Full article
(This article belongs to the Special Issue Application of Regenerative Medicine in the Field of Veterinary Medicine)
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18 pages, 3454 KiB  
Article
Isolation and Characterization of Canine Adipose-Derived Mesenchymal Stromal Cells: Considerations in Translation from Laboratory to Clinic
by Michael A. Rivera Orsini, Emine Berfu Ozmen, Alyssa Miles, Steven D. Newby, Nora Springer, Darryl Millis and Madhu Dhar
Animals 2024, 14(20), 2974; https://doi.org/10.3390/ani14202974 - 15 Oct 2024
Viewed by 3102
Abstract
In allogeneic MSC implantation, the cells are isolated from a donor different from the recipient. When tested, allogeneic MSCs have several advantages over autologous ones: faster cell growth, sufficient cell concentration, and readily available cells for clinics. To ensure the safe and efficient [...] Read more.
In allogeneic MSC implantation, the cells are isolated from a donor different from the recipient. When tested, allogeneic MSCs have several advantages over autologous ones: faster cell growth, sufficient cell concentration, and readily available cells for clinics. To ensure the safe and efficient use of allogeneic MSCs in clinics, the MSCs need to be first tested in vitro. With this study, we paved the way by addressing the in vitro aspects of canine adipose-derived MSCs, considering the limited studies on the clinical use of canine cells. We isolated cAD-MSCs from canine falciform ligament fat and evaluated their viability and proliferation using an MTS assay. Then, we characterized the MSC-specific antigens using immunophenotyping and immunofluorescence and demonstrated their potential for in vitro differentiation. Moreover, we established shipping and cryobanking procedures to lead the study to become an off-the-shelf therapy. During expansion, the cells demonstrated a linear increase in cell numbers, confirming their proliferation quantitatively. The cells showed viability before and after cryopreservation, demonstrating that cell viability can be preserved. From a clinical perspective, the established shipping conditions demonstrated that the cells retain their viability for up to 48 h. This study lays the groundwork for the potential use of allogeneic cAD-MSCs in clinical applications. Full article
(This article belongs to the Special Issue Application of Regenerative Medicine in the Field of Veterinary Medicine)
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