Molecular Genomics and Genetics in Animal Prion Diseases

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1044

Special Issue Editor


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Guest Editor
Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Jeonbuk, Republic of Korea
Interests: prion diseases; neurodegenerative disorders; prion protein gene (PRNP); prion-like protein gene (PRND); shadow of prion protein gene (SPRN); prion-related protein gene (PRNT); genetics; genomics
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Special Issue Information

Dear Colleagues,

Prion diseases are fatal, acute, and irreversible neurodegenerative disorders that affect a wide range of hosts. These diseases include scrapie in sheep and goats, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in elk and deer, and Creutzfeldt–Jakob disease (CJD) in humans. It has been nearly three centuries since the first discovery of prion disease in sheep, which occurred in 1732. However, the exact mechanisms underlying the progression and causative agents of prion diseases remain unclear. To date, genetic factors—such as polymorphisms and mutations in prion disease-related genes—are known to play a pivotal role in prion diseases.

This Special Issue of Animals, titled “Molecular Genomics and Genetics in Animal Prion Diseases”, will focus on research articles and reviews related to the genomics and genetics of animal prion diseases. Emphasis will be placed on genetic susceptibilities and the functional roles of prion disease-related genes, aiming to further our understanding of the pathogenesis of prion diseases in animals.

Dr. Byung-Hoon Jeong
Guest Editor

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Keywords

  • prion diseases
  • prion protein gene (PRNP)
  • prion-like protein gene (PRND)
  • shadow of prion protein gene (SPRN)
  • prion-related protein gene (PRNT)
  • bovine spongiform encephalopathy (BSE)
  • scrapie
  • chronic wasting disease (CWD)
  • genetics
  • genomics
  • polymorphism

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Published Papers (1 paper)

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Research

16 pages, 2108 KiB  
Article
First Report of Polymorphisms and Genetic Characteristics of Prion-like Protein Gene (PRND) in Cats
by Min-Ju Jeong, Yong-Chan Kim and Byung-Hoon Jeong
Animals 2024, 14(23), 3438; https://doi.org/10.3390/ani14233438 - 27 Nov 2024
Viewed by 747
Abstract
Prion diseases are fatal neurodegenerative disorders caused by the misfolding of the normal cellular prion protein (PrPC) into its infectious isoform (PrPSc). Although prion diseases in humans, sheep, goats, and cattle have been extensively studied, feline spongiform encephalopathy (FSE) [...] Read more.
Prion diseases are fatal neurodegenerative disorders caused by the misfolding of the normal cellular prion protein (PrPC) into its infectious isoform (PrPSc). Although prion diseases in humans, sheep, goats, and cattle have been extensively studied, feline spongiform encephalopathy (FSE) remains poorly understood. Genetic factors, particularly polymorphisms in the prion protein gene (PRNP) and prion-like protein gene (PRND), have been linked to prion disease susceptibility in various species. However, no studies have yet investigated the PRND gene in cats with respect to prion diseases. Therefore, we investigated polymorphisms in the feline PRND gene and analyzed their genetic characteristics. We sequenced the coding region of the PRND gene using samples from 210 domestic cats and determined the genotype and allele frequencies of PRND polymorphisms. We identified thirteen novel single nucleotide polymorphisms (SNPs), including six non-synonymous variants and one insertion/deletion (InDel) in the feline PRND gene. Four of the non-synonymous SNPs were predicted to have deleterious effects on the Doppel protein’s structure and function. Notably, the SNP c.97A>G (I33V) showed potential structural clashes, and the others formed additional hydrogen bonds. The LD analysis revealed strong genetic associations between the PRND SNPs and the PRNP InDel, suggesting linkage between these loci in cats. This study identifies novel PRND polymorphisms in domestic cats and provides new insights into the genetic factors underlying feline susceptibility to prion diseases. The strong genetic linkage between PRND and PRNP polymorphisms, coupled with predictions of detrimental effects on Doppel protein structure, suggests that PRND gene variants could influence prion disease progression in cats. These findings provide a foundational framework for future studies on the functional implications of PRND polymorphisms in FSE. To the best of our knowledge, this study is the first report on the genetic characteristics of PRND polymorphisms in cats. Full article
(This article belongs to the Special Issue Molecular Genomics and Genetics in Animal Prion Diseases)
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