Intestinal Health and Immunomodulation in Swine

A special issue of Agriculture (ISSN 2077-0472). This special issue belongs to the section "Farm Animal Production".

Deadline for manuscript submissions: 25 July 2025 | Viewed by 537

Special Issue Editors


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Guest Editor
National Research and Development Institute for Biology and Animal Nutrition, 077015 Balotesti, Romania
Interests: swine; immunomodulation; intestinal health; biochemistry; nutritional biochemistry; mycotoxins

E-Mail Website
Guest Editor
Laboratory of Animal Biology, National Institute for Research and Development for Biology and Animal Nutrition, Calea Bucuresti No. 1, Balotesti, 077015 Ilfov, Romania
Interests: swine; immunomodulation; immunonutrition; intestinal health; biochemistry; nutritional biochemistry; mycotoxins
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Special Issue Information

Dear Colleagues,

Intestinal health is a crucial topic in Farm Animal Production due to the increasing incidence and mortality caused by intestinal diseases, especially in swine. Gut health encompasses not only well-being issues but also economic losses for farmers and the swine industry at large. Due to the native sensitivity of a pig’s gut, its functionality can be disrupted by ingesting feed contaminants such as bacteria, mycotoxins, heavy metals, pesticides, or other common xenobiotics in their feed. In pigs, the most common toxic effects observed are diarrhea, vomiting, reduced appetite, or weight loss. However, despite visible symptoms, some agents can trigger the immune response, and long-term exposure to low doses of these contaminants could also negatively affect pigs’ health. Equally important is the study of the beneficial effects that certain bioactive compounds could have in maintaining the intestinal health of pigs.

This Special Issue focuses on intestinal health, studying the factors and mechanisms that can damage the intestinal epithelium and trigger the immune response. Our goal is also to find new ways to diagnose, prevent, and treat intestinal-related diseases, thus supporting the health status of pigs and the economy.

Dr. Valeria Cristina Bulgaru
Dr. Gina Pistol
Guest Editors

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Keywords

  • swine
  • intestinal health
  • immunomodulation

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Published Papers (1 paper)

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Research

12 pages, 1914 KiB  
Article
Dietary Glutamine Supplementation Enhances Growth Performance and Jejunum Development in Kele and Large White Hybrid Weaned Piglets
by Longjuan Tan, Yujie Cheng, Guowei Liu, Yiyu Zhang and Min Zhu
Agriculture 2025, 15(9), 924; https://doi.org/10.3390/agriculture15090924 - 24 Apr 2025
Viewed by 198
Abstract
Glutamine (Gln), a functional amino acid, is effective in reducing weaning stress in piglets. This study aims to assess the effects of dietary Gln supplementation on intestinal morphology and functionality, as well as the growth performance of Kele and Large White hybrid weaned [...] Read more.
Glutamine (Gln), a functional amino acid, is effective in reducing weaning stress in piglets. This study aims to assess the effects of dietary Gln supplementation on intestinal morphology and functionality, as well as the growth performance of Kele and Large White hybrid weaned piglets. Forty-eight piglets aged 30 days (Kele × Large White) were randomly divided into three groups: the control group, which received a basal diet supplemented with 2.45% alanine to maintain an isonitrogenous balance; the 1% Gln group, which received the basal diet with 1.0% Gln and 1.23% alanine; and the 2% Gln group, which was given the basal diet supplemented with 2.0% Gln. Intestinal samples from 16 piglets in the control and 1% Gln groups were collected randomly on day 29 of the experiment. The results show that, compared to the control group, the 1% Gln group experienced an increase in the average daily gain (ADG) and gain-to-feed ratio (G:F). In contrast, the 2% Gln group did not demonstrate significant differences in either the ADG or G:F compared to the control group. Additionally, there were no differences in feed intake among the groups. Notably, weaned piglets in both the 1% and 2% Gln supplementation groups had reduced diarrhea rates compared to those in the control group. Furthermore, 1% Gln supplementation significantly increased villus height in both the duodenum and jejunum and the ratio of villus height to crypt depth in weaned piglets. Subsequent analyses revealed that 1% Gln supplementation increased the mRNA expression of antioxidant genes, specifically catalase and superoxide dismutase. Additionally, the mRNA levels of the intestinal tight junction genes zonula occludens-1, Claudin 1, and Occludin in the jejuna of weaned piglets were found to be elevated. In summary, incorporating 1% Gln into the diet can significantly improve intestinal functionality and promote growth in Kele and Large White hybrid weaned piglets. Full article
(This article belongs to the Special Issue Intestinal Health and Immunomodulation in Swine)
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