Life | Hot Papers on Oxidative Stress and Human Disease

Oxidative stress is the imbalance of reactive oxygen species (ROS) and endogenous antioxidants; it is the driving cause of many human diseases, including neurodegenerative diseases, cancer, cardiovascular diseases, immune system disorders, and musculoskeletal diseases. The dramatically increased human lifespan leads to the increased prevalence of these oxidative-stress-related diseases, which may be prevented and treated in order to reduce the economic and psychological burdens for patients, their families, and society, which are currently showing a progressive increase.

1. “The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases”
   by Carmine Izzo, Paolo Vitillo, Paola Di Pietro, Valeria Visco, Andrea Strianese, Nicola Virtuoso, Michele Ciccarelli, Gennaro Galasso, Albino Carrizzo and Carmine Vecchione
   Life 2021, 11(1), 60; https://doi.org/10.3390/life11010060
   Available online: https://www.mdpi.com/2075-1729/11/1/60

2. “Oxidative Stress and the Neurovascular Unit”
   by Carmela Rinaldi, Luigi Donato, Simona Alibrandi, Concetta Scimone, Rosalia D’Angelo and Antonina Sidoti
   Life 2021, 11(8), 767; https://doi.org/10.3390/life11080767
   Available online: https://www.mdpi.com/2075-1729/11/8/767

3. “Oxidative Stress, Mitochondrial Function and Adaptation to Exercise: New Perspectives in Nutrition”
   by Nancy Vargas-Mendoza, Marcelo Angeles-Valencia, Ángel Morales-González, Eduardo Osiris Madrigal-Santillán, Mauricio Morales-Martínez, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, José Gutiérrez-Salinas, César Esquivel-Chirino, Germán Chamorro-Cevallos et al.
   Life 2021, 11(11), 1269; https://doi.org/10.3390/life11111269
   Available online: https://www.mdpi.com/2075-1729/11/11/1269

4. “Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses”
   by Inseok Choi, Hyewon Son and Jea-Hyun Baek
   Life 2021, 11(1), 69; https://doi.org/10.3390/life11010069
   Available online: https://www.mdpi.com/2075-1729/11/1/69

5. “Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse Diseases”
   by Wang-Soo Lee, Woojin Ham and Jaetaek Kim
   Life 2021, 11(12), 1301; https://doi.org/10.3390/life11121301
   Available online: https://www.mdpi.com/2075-1729/11/12/1301

6. “Kaempferol-3-O-Glucuronide Ameliorates Non-Alcoholic Steatohepatitis in High-Cholesterol-Diet-Induced Larval Zebrafish and HepG2 Cell Models via Regulating Oxidation Stress”
   by Yang Deng, Ji Ma, Xin Weng, Yuqin Wang, Maoru Li, Tingting Yang, Zhiyang Dou, Zhiqi Yin and Jing Shang
   Life 2021, 11(5), 445; https://doi.org/10.3390/life11050445
   Available online: https://www.mdpi.com/2075-1729/11/5/445

7. “Protection against Osteoarthritis Symptoms by Aerobic Exercise with a High-Protein Diet by Reducing Inflammation in a Testosterone-Deficient Animal Model”
   by Sunmin Park, Suna Kang, Da Sol Kim and Ting Zhang
   Life 2022, 12(2), 177; https://doi.org/10.3390/life12020177
   Available online: https://www.mdpi.com/2075-1729/12/2/177

8. “Regulation of Oxidative Stress by Long Non-Coding RNAs in Vascular Complications of Diabetes”
   by Pei-Ming Chu, Cheng-Chia Yu, Kun-Ling Tsai and Pei-Ling Hsieh
   Life 2022, 12(2), 274; https://doi.org/10.3390/life12020274
   Available online: https://www.mdpi.com/2075-1729/12/2/274

9. “Pro-Oxidant/Antioxidant Balance during a Prolonged Exposure to Moderate Altitude in Athletes Exhibiting Exercise-Induced Hypoxemia at Sea-Level”
   by Antoine Raberin, Elie Nader, Jorge Lopez Ayerbe, Gauthier Alfonsi, Patrick Mucci, Chantal L. Rytz, Vincent Pialoux and Fabienne Durand
   Life 2021, 11(3), 228; https://doi.org/10.3390/life11030228
   Available online: https://www.mdpi.com/2075-1729/11/3/228

10. “Oxidative Stress Management in Cardiorenal Diseases: Focus on Novel Antidiabetic Agents, Finerenone, and Melatonin”
    by Panagiotis Theofilis, Aikaterini Vordoni and Rigas G. Kalaitzidis
    Life 2022, 12(10), 1663; https://doi.org/10.3390/life12101663
    Available online: https://www.mdpi.com/2075-1729/12/10/1663