Regulation of Oxidative Stress by Long Non-Coding RNAs in Vascular Complications of Diabetes
Abstract
:1. Diabetes Mellitus and Oxidative Stress
2. Long Non-Coding RNA
3. Diabetic Nephropathy
3.1. HOTAIR
3.2. MALAT1
3.3. MEG3
3.4. GAS5
3.5. SNHG16
3.6. CASC2
4. Diabetic Cardiomyopathy and Vascular Complications
4.1. HOTAIR
4.2. MEG3
5. Diabetic Retinopathy and Diabetic Cataract
5.1. HOTAIR
5.2. MALAT1
5.3. MEG3
5.4. SNHG16
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Diabetic Complications | LncRNA | Expression Level | Cells or Tissues | Interacting Factors/Pathways | Ref. |
---|---|---|---|---|---|
Diabetic Nephropathy | MALAT1 | Upregulated | Kidney cortices in STZ-injected C57BL/6 mice | [18] | |
Diabetic Nephropathy | MALAT1 | Patients with DN | SOD | [19] | |
Diabetic Nephropathy | MALAT1 | Mouse podocyte MPC-5 cells | KLF5 | [20] | |
Diabetic Nephropathy | MALAT1 | Mouse podocyte MPC-5 cells | Nrf2/HO-1 signaling | [22] | |
Diabetic Nephropathy | MEG3 | Upregulated | Podocytes of STZ-induced mice | drp1 | [27] |
Diabetic Nephropathy | MEG3 | Upregulated | HG-treated mesangial cells | miR-181a | [28] |
Diabetic Nephropathy | MEG3 | Upregulated | Serum of patients with DN | miR-145 | [29] |
Diabetic Nephropathy | MEG3 | Downregulated | Renal tissues of patients with DN and HG-treated podocytes | Wnt/β-catenin signaling | [34] |
Diabetic Nephropathy | GAS5 | Downregulated | HG-induced proximal tubular cells | miR-452-5p/SOD axis | [36] |
Diabetic Nephropathy | GAS5 | Downregulated | HG-treated mesangial cells | miR-221/SIRT1 axis | [37] |
Diabetic Nephropathy | GAS5 | Upregulated | Kidneys of the HFD/ STZ-induced diabetic mice | [38] | |
Diabetic Nephropathy | SNHG16 | Upregulated | Serum of DN patients and HG-treated podocytes | miR-106a/KLF9 axis | [44] |
Diabetic Nephropathy | SNHG16 | Upregulated | HG-treated mesangial cells | [45] | |
Diabetic Nephropathy | CASC2 | Downregulated | Serum of DN patients and podocyte cells | [49] | |
Diabetic Nephropathy | CASC2 | Downregulated | Tissues in db/db diabetic mouse and HG-treated mesangial cells and podocytes | [50] | |
Diabetic Nephropathy | CASC2 | Downregulated | HG-treated podocyte cells | miR-133b/FOXP1 axis | [52] |
Diabetic Cardiomyopathy | HOTAIR | Downregulated | Myocardial tissues and serum of diabetic cardiomyopathy patients | [61] | |
Diabetic Cardiomyopathy | HOTAIR | Downregulated | Diabetic hearts in STZ-injected C57/B6 mice andHG-stimulated H9c2 cells | miR-34a/SIRT1 axis | [64] |
Diabetic Cardiomyopathy | MEG3 | Upregulated | HG-treated cardiomyocytes | miR-145 | [66] |
Diabetic Retinopathy | HOTAIR | Upregulated | HG-treated human retinal endothelial cells | [74] | |
Diabetic Retinopathy | HOTAIR | HG-treated human retinal endothelial cells | LSD1/MnSOD axis | [75,76] | |
Diabetic Retinopathy | MALAT1 | Upregulated | Diabetic retinas using clinical samples, STZ-induced type I DM mice | [77] | |
Diabetic Retinopathy | MALAT1 | db/db type 2 DM mice | [78] | ||
Diabetic Retinopathy | MALAT1 | Keap1-Nrf2 axis | [79,80] | ||
Diabetic Retinopathy | MALAT1 | HG-treated human lens epithelial cells | SP1 and p38MAPK pathway | [83] | |
Diabetic Retinopathy | MEG3 | Downregulated | HG-treated Müller cells | miR-204/SIRT1 axis | [85] |
Diabetic Retinopathy | MEG3 | HG-treated retinal pigment epithelium cells | miR-93/Nrf2 axis | [87] | |
Diabetic Retinopathy | MEG3 | HG-treated retina epithelial cells | miR-34a/SIRT1 axis | [88] | |
Diabetic Retinopathy | SNHG16 | Upregulated | HG-treated retinal microvascular endothelial cells | [89] | |
Diabetic Retinopathy | SNHG16 | HG-treated retinal microvascular endothelial cells | miR-195/mfn2 axis | [90] | |
Diabetic Retinopathy | SNHG16 | HG-treated retinal microvascular endothelial cells | miR-20a-5p/E2F1 axis | [91] |
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Chu, P.-M.; Yu, C.-C.; Tsai, K.-L.; Hsieh, P.-L. Regulation of Oxidative Stress by Long Non-Coding RNAs in Vascular Complications of Diabetes. Life 2022, 12, 274. https://doi.org/10.3390/life12020274
Chu P-M, Yu C-C, Tsai K-L, Hsieh P-L. Regulation of Oxidative Stress by Long Non-Coding RNAs in Vascular Complications of Diabetes. Life. 2022; 12(2):274. https://doi.org/10.3390/life12020274
Chicago/Turabian StyleChu, Pei-Ming, Cheng-Chia Yu, Kun-Ling Tsai, and Pei-Ling Hsieh. 2022. "Regulation of Oxidative Stress by Long Non-Coding RNAs in Vascular Complications of Diabetes" Life 12, no. 2: 274. https://doi.org/10.3390/life12020274