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Sclerosis, Volume 3, Issue 2

2025 June - 12 articles

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Articles (12)

  • Review
  • Open Access
5,092 Views
32 Pages

Systemic sclerosis (SSc) is a multifaceted autoimmune disease in which the complex interplay of genetic predisposition and environmental factors triggers aberrant immune responses, ultimately leading to vasculopathy and fibrosis. This review offers a...

  • Systematic Review
  • Open Access
2,136 Views
18 Pages

Background/Objectives: Late-onset multiple sclerosis (LOMS), characterized by an onset of disease at ≥50 years, is a distinct subset of multiple sclerosis (MS) with unique clinical and demographic features. While environmental factors such as smok...

  • Systematic Review
  • Open Access
2,089 Views
20 Pages

The Metabolomic View of Systemic Sclerosis—A Systematic Literature Review

  • Sebastian T. Jendrek,
  • Franziska Schmelter,
  • Christian Sina,
  • Ulrich L. Günther and
  • Gabriela Riemekasten

The mortality risk in systemic sclerosis (SSc) is primarily determined by pulmonary involvement (interstitial lung disease (ILD), pulmonary fibrosis), pulmonary arterial hypertension (PAH), and cardiac involvement. With timely and intensive treatment...

  • Review
  • Open Access
3 Citations
6,287 Views
16 Pages

Background: Systemic sclerosis (SSc) is a rare connective tissue disease characterized by vasculopathy, autoimmunity, and fibrosis. Due to its low prevalence and heterogeneous clinical presentation, early diagnosis remains challenging, often delaying...

  • Review
  • Open Access
2,904 Views
13 Pages

MicroRNA as a Potential Biomarker for Amyotrophic Lateral Sclerosis (ALS)

  • José Augusto Nogueira-Machado,
  • Amanda Tábita da Silva Albanaz and
  • Fabiana Rocha-Silva

Background: Amyotrophic lateral sclerosis (ALS) is a rare, incurable, and fatal neurodegenerative disease that affects the muscles and results in paralysis. The onset and development of ALS involve complex interactions among metabolic signaling, gene...

  • Feature Paper
  • Review
  • Open Access
1 Citations
4,387 Views
19 Pages

Harnessing Artificial Intelligence for the Diagnosis, Treatment and Research of Multiple Sclerosis

  • Manisha S. Patil,
  • Linda Y. Lin,
  • Rachel K. Ford,
  • Elizaveta J. James,
  • Stella Morton,
  • Felix Marsh-Wakefield,
  • Simon Hawke and
  • Georges E. Grau

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system affecting over 2.8 million people around the world. Artificial intelligence (AI) is becoming increasingly utilised in many areas, including patient care for MS. AI is revo...

  • Article
  • Open Access
1,647 Views
13 Pages

Introduction: Cognitive impairment (CI) is recognized as a very frequent feature of persons with multiple sclerosis (pwMSs). Multiple studies have demonstrated the effectiveness of cognitive rehabilitation (CR) in improving CI linked to cerebral func...

  • Review
  • Open Access
1,237 Views
20 Pages

Kinesiotherapeutic Possibilities and Molecular Parameters in Multiple Sclerosis

  • Katarzyna Wiszniewska,
  • Małgorzata Wilk,
  • Małgorzata Wiszniewska,
  • Joanna Poszwa,
  • Oliwia Szymanowicz,
  • Wojciech Kozubski and
  • Jolanta Dorszewska

Multiple sclerosis (MS) is a chronic and incurable neurological disease of the central nervous system. Three main forms of the disease have been distinguished: relapsing–remitting form (RRMS), secondary progressive form (SPMS), and primary prog...

  • Opinion
  • Open Access
1,366 Views
9 Pages

Behavioral activation therapy (BAT) was initially developed to treat depression and was subsequently extended as a transdiagnostic therapy for other psychiatric and neurocognitive disorders. However, research on its impact in people with multiple scl...

  • Feature Paper
  • Article
  • Open Access
2,067 Views
15 Pages

Background/Objectives: Health locus of control (LOC) refers to one’s perceptions of who or what controls one’s health. Recent evidence has found that chance LOC (CLOC) is associated with improved quality of life (QoL) in multiple sclerosi...

  • Communication
  • Open Access
1,352 Views
11 Pages

Biomarker Identification in Patients with Multiple Sclerosis Treated with Autologous Hematopoietic Stem Cell Transplantation

  • Moisés Manuel Gallardo-Pérez,
  • Alejandro Ruiz-Argüelles,
  • Guillermo José Ruiz-Argüelles,
  • Virginia Reyes-Núñez,
  • Silvia Soto-Olvera and
  • Solón Javier Garcés-Eisele

Introduction: Approximately 80% of individuals with multiple sclerosis (MS) have a positive response to autologous hematopoietic stem cell transplantation (aHSCT). Markers that may predict the transplant outcome are necessary. The objective of this w...

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Sclerosis - ISSN 2813-3064