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Article

Effect of Degradation and Osteoarthritis on the Viscoelastic Properties of Human Knee Articular Cartilage: An Experimental Study and Constitutive Modeling

1
WMG, University of Warwick, Coventry CV4 7AL, UK
2
School of Engineering, University of Tabriz, Tabriz 5166616471, Iran
*
Author to whom correspondence should be addressed.
Academic Editor: Jim Dickey
Biomechanics 2021, 1(2), 225-238; https://doi.org/10.3390/biomechanics1020019
Received: 4 June 2021 / Revised: 11 August 2021 / Accepted: 13 August 2021 / Published: 20 August 2021
Articular cartilage, as a hydrated soft tissue which covers diarthrodial joints, has a pivotal role in the musculoskeletal system. Osteoarthritis is the most common degenerative disease that affects most individuals over the age of 55. This disease affects the elasticity, lubrication mechanism, damping function, and energy absorption capability of articular cartilage. In order to investigate the effect of osteoarthritis on the performance of articular cartilage, the mechanical behavior of human knee articular cartilage was experimentally investigated. Progressive cyclic deformation was applied beyond the physiological range to facilitate degradation of the tissue. The relaxation response of the damaged tissue was modeled by means of a fractional-order nonlinear viscoelastic model in the framework of finite deformations. It is shown that the proposed fractional model well reproduces the tissue’s mechanical behavior using a low number of parameters. Alteration of the model parameters was also investigated throughout the progression of tissue damage. This helps predict the mechanical behavior of the osteoarthritic tissue based on the level of previous damage. It is concluded that, with progression of osteoarthritis, the articular cartilage loses its viscoelastic properties such as damping and energy absorption capacity. This is also accompanied by a loss of stiffness which deteriorates more rapidly than viscosity does throughout the evolution of tissue damage. These results are thought to be significant in better understanding the degradation of articular cartilage and the progression of OA, as well as in the design of artificial articular cartilages. View Full-Text
Keywords: articular cartilage; degradation; osteoarthritis; viscoelasticity; fractional-order model articular cartilage; degradation; osteoarthritis; viscoelasticity; fractional-order model
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MDPI and ACS Style

Khajehsaeid, H.; Abdollahpour, Z.; Farahmandpour, H. Effect of Degradation and Osteoarthritis on the Viscoelastic Properties of Human Knee Articular Cartilage: An Experimental Study and Constitutive Modeling. Biomechanics 2021, 1, 225-238. https://doi.org/10.3390/biomechanics1020019

AMA Style

Khajehsaeid H, Abdollahpour Z, Farahmandpour H. Effect of Degradation and Osteoarthritis on the Viscoelastic Properties of Human Knee Articular Cartilage: An Experimental Study and Constitutive Modeling. Biomechanics. 2021; 1(2):225-238. https://doi.org/10.3390/biomechanics1020019

Chicago/Turabian Style

Khajehsaeid, Hesam, Zanko Abdollahpour, and Hedyeh Farahmandpour. 2021. "Effect of Degradation and Osteoarthritis on the Viscoelastic Properties of Human Knee Articular Cartilage: An Experimental Study and Constitutive Modeling" Biomechanics 1, no. 2: 225-238. https://doi.org/10.3390/biomechanics1020019

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