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BioChem, Volume 4, Issue 3

September 2024 - 6 articles

Cover Story: Phenolic-rich extracts from Origanum dictamnus and Thymus vulgaris were utilized for chemical characterization, biological evaluation, and the preparation of bioactive-rich hydrogels. Ultrasound-assisted methanolic extraction was employed to prepare the extracts, whose phenolic profiles were then characterized with components quantified using LC-MSⁿ and HPLC-DAD, respectively. The extracts were evaluated for their antioxidant, antibacterial, and enzyme-inhibiting activities. Molecular docking studies were also conducted to provide deeper insights into the interactions between the extracts and the tested enzymes. Additionally, the extracts were incorporated into gelatin-based hydrogels using a deep eutectic solvent (DES) as both a plasticizer and solvent. The hydrogels were then further subjected to antimicrobial testing. View this paper

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Review

6 Citations

3,421 Views

32 Pages

Mechanistic Insights into Targeting SARS-CoV-2 Papain-like Protease in the Evolution and Management of COVID-19

Nonjabulo Ntombikhona Magwaza,
Aganze Gloire-Aimé Mushebenge,
Samuel Chima Ugbaja,
Nonkululeko Avril Mbatha,
Rene B. Khan and
Hezekiel M. Kumalo

BioChem2024, 4(3), 268-299;https://doi.org/10.3390/biochem4030014

23 September 2024

The COVID-19 pandemic, instigated by the emergence of the novel coronavirus, SARS-CoV-2, created an incomparable global health crisis. Due to its highly virulent nature, identifying potential therapeutic agents against this lethal virus is crucial. P...

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Article

1 Citations

2,161 Views

16 Pages

Neurotransmitter Availability and Anti-Inflammatory and Antioxidant Effects of Subacute Administration of Aloysia gratissima (Gillies & Hook) Tronc. and Rutin in Female Wistar Rats

Gênifer Erminda Schreiner,
Elizandra Gomes Schmitt,
Gabriela Escalante Brittes,
Laura Smolski dos Santos,
Luana Tamires Maders,
Itamar Luís Gonçalves,
Sílvia Muller de Moura Sarmento,
Nessana Dartora and
Vanusa Manfredini

BioChem2024, 4(3), 252-267;https://doi.org/10.3390/biochem4030013

20 September 2024

Background: Levels of chronic inflammation, oxidative stress, and neurotransmitter availability are altered in depressed patients and can be used as biological markers. This study aimed to analyze these markers in female Wistar rats under chronic inf...

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Review

2 Citations

2,910 Views

16 Pages

The Prospect and Challenges of Repurposing Established Drugs in Pulmonary Arterial Hypertension

Sila Ozlem Sener,
Rateep Nasim and
Talat Nasim

BioChem2024, 4(3), 236-251;https://doi.org/10.3390/biochem4030012

10 September 2024

Pulmonary arterial hypertension (PAH) is a progressive disorder caused by the narrowing of small blood vessels in the lungs, which, in the absence of therapies, leads to right heart failure and premature death. No cure for this devastating disorder i...

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Article

2,903 Views

19 Pages

Tillandsia usneoides Ethanolic Extract Induces Cytotoxicity in SW480 Colon Cancer Cell Line via PPARγ Modulation

María Paula López,
María Camila Jiménez,
Julián Esteban Contreras,
Laura Rojas,
Susana Fiorentino and
José Iglesias

BioChem2024, 4(3), 217-235;https://doi.org/10.3390/biochem4030011

26 August 2024

Colorectal cancer (CRC) is a prevalent and deadly tumor worldwide. Understanding the molecular mechanisms underlying CRC development will improve treatment outcomes and patient survival. Natural molecules and metabolites from plants, such as Tillands...

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Review

10 Citations

5,974 Views

28 Pages

Oxidative Stress-Induced Gastrointestinal Diseases: Biology and Nanomedicines—A Review

Maryam Rezvani

BioChem2024, 4(3), 189-216;https://doi.org/10.3390/biochem4030010

29 July 2024

Gastrointestinal diseases have been among the main concerns of medical and scientific societies for a long time. Several studies have emphasized the critical role of oxidative stress in the pathogenesis of the most common gastrointestinal diseases. T...

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Article

5 Citations

3,394 Views

23 Pages

Evaluation of Antioxidant, Antibacterial and Enzyme-Inhibitory Properties of Dittany and Thyme Extracts and Their Application in Hydrogel Preparation

Stamatia Spyrou,
Myrto G. Bellou,
Angelos Papanikolaou,
Konstantina Nakou,
Vasiliki G. Kontogianni,
Alexandra V. Chatzikonstantinou and
Haralambos Stamatis

BioChem2024, 4(3), 166-188;https://doi.org/10.3390/biochem4030009

10 July 2024

In the present work, methanolic extracts from thyme and dittany plants were prepared and characterized in terms of their polyphenolic content through analytical and spectrophotometric techniques. Rosmarinic acid, thymol and carvacrol were found to be...

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