Cancer Molecular Biology and Drug Discovery
A special issue of BioChem (ISSN 2673-6411).
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 3230
Special Issue Editor
Interests: cancer biology; bioinformatics; drug repurposing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer is a major health issue worldwide, with an increasing global burden in the coming years. Some malignancies, such as colorectal, breast, prostate, and pancreatic cancers, are still incurable in advanced stages. Thus, more effective anticancer drugs are always urgently needed. The process of drug discovery is still risky, lengthy, and costly, and only a few new anticancer drugs have received approval in recent years. Drug repurposing is an unconventional drug discovery approach to explore new disease indications from existing clinical drugs. Even shelved drugs that never enter or fail during clinical trials might be rescued if novel mechanisms of action (MOAs) or targets are identified. Polypharmacology describes the ability of a drug to affect more than one molecular target, which is now commonly accepted as a basic property of small molecules and serves as a foundational principle for drug repurposing. Exploring polypharmacology is highly useful for discovering drugs’ novel MOAs to improve their therapeutic efficacies and treat different diseases. The advantages of drug repurposing include a reduction in cost and the bypass of safety concerns because extensive drug data are often available.
This Special Issue will focus on the development of novel cancer therapy based on polypharmacology and drug repurposing strategies. We welcome original research articles and review articles in this field.
Dr. Pei-Ming Yang
Guest Editor
Manuscript Submission Information
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Keywords
- cancer therapy
- cancer biology
- drug discovery
- drug repurposing
- polypharmacology
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