Analytica, Volume 7, Issue 1

Phosphonyl tyrosine is one of the main biomarkers to confirm exposure to highly lethal organophosphorus nerve agents (OPNAs) in vivo. However, a critical challenge remains unresolved: ionization suppression occurs during the analysis of phosphonyl ty...

Impurity profiling is of significant analytical and regulatory importance, particularly in the context of lifecycle quality management. A robust chaotropic chromatography method was developed for the determination of olanzapine and its two oxidative...

Light-sensitive protecting chemical groups play an important role in the control of chemical reactions with high spatial and temporal resolution. Various forms of o-nitrobenzyl as a protecting compound are used for light-directed DNA synthesis. The s...

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a powerful technique for polymer identification because it can ionize intact macromolecules with large molecular weights (>100 kDa) and detect them over...

The forensic reliability of biological fluids in sexual assault investigations depends on substrate type, environmental exposure, time since deposition, and analytical methodology. This systematic review evaluates the forensic reliability of major bi...

Objectives: Using high-performance liquid chromatography (HPLC), we developed and validated an in vitro assay for the quantitative determination of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) activity, supplementing limited current...

White Analytical Chemistry (WAC) provides a holistic framework for evaluating analytical methods by balancing analytical performance, environmental sustainability, and practical efficiency. Existing WAC assessment tools offer structured evaluation bu...

High-resolution mass spectrometry (HRMS) enables non-targeted detection of drugs and metabolites in complex matrices. Phase II metabolites—especially glucuronides—are often the only detectable biomarkers in late or postmortem samples but...

Taraxacum mirabile Wagenitz, one of the endemic riches of Anatolia, is a species that has remained largely unexplored regarding its enzyme inhibition profile despite its pharmacological potential. The effects of T. mirabile aerial and root extracts,...

A simple mechanical polishing treatment of commercial solid-gold electrodes (SGEs) can renew the active gold surface, reduce manufacturing-related grooves, and markedly improve the repeatability of geometric-area estimation and the analytical perform...

The all-d-enantiomeric-peptide RD2 was developed for the treatment of Alzheimer’s disease. This study aimed to develop a specific and highly sensitive liquid chromatography-mass-spectrometric (UHPLC-ESI-QTOF) method for quantifying RD2 in the m...

In the context of the energy transition and the increasing deployment of low-carbon gases (hydrogen, biomethane), reliable analytical monitoring is required to support integrity assessment and traceability of gas infrastructures under diverse on-site...

The primary objective of the current study is to establish and validate for the first time a method to determine and quantify praziquantel (PZQ) and its main degradation products loaded in poly(methyl methacrylate–co-2-(diethylamino)ethyl metha...

The rapid growth and diversification of the cosmetic industry have led to increasingly complex formulations containing numerous bioactive ingredients, excipients, and synthetic additives, often delivered through advanced nanostructured systems. Ensur...

Molting is an important biological and physiological stage in penguins, influenced by environmental and nutritional factors. Feather composition analysis before and after molting can consequently place boundaries on element bioaccumulation and excret...

Oats (Avena sativa L.) are a rich source of β-d-glucans, dietary fibre, proteins, and lipids. However, the behaviour of these components in wheat–oat composite systems during baking, particularly with regard to matrix-dependent analytical...

Titanium dioxide (TiO₂) nano- and submicrometric particles’ widespread use in different sectors raised concerns about human and environmental exposure. The validation of analytical methods is essential to ensure reliability in risk assessment s...

The present paper reports the preparation of a nanocomposite thin film consisting of calcium itaconate and graphene oxide (GO). The composite is a black powder consisting of individual shiny prismatic crystals at varying degrees of maturity. The crys...

Interactions between alkaline solutions and the surface of pyrolytically coated graphite tubes (PCGTs) with/without a platform for determination of vanadium using high-resolution continuum source graphite furnace atomic absorption spectrometry (HR CS...

Iodine is essential for thyroid hormone synthesis and is particularly critical during pregnancy, where excess and mainly its deficiencies can impair fetal neurodevelopment and increase maternal complications. Bromine has also gained attention due to...

The objective of this research is to develop environmentally friendly, risk-free and effective adsorbent composite beads that remove Cu(II) ions from aqueous solutions using cost-effective biopolymers (Carboxymethylcellulose (CMC) and sodium alginate...

Additive manufacturing, particularly fused deposition modeling (FDM), has emerged as a promising approach for producing electrochemical sensors based on conductive thermoplastic composites. In this study, the effects of various printing parameters (e...

The urgent need for effective therapies against cancer and antimicrobial-resistant pathogens motivates the development of novel metal-based complexes. Herein, we report the synthesis and characterization of four novel cobalt(II) complexes with biolog...

In clinical medicine it is of interest to know vitamin C blood levels. There are numerous variations in published sample preparation methods for quantifying vitamin C using HPLC. For the determination of vitamin C in human probes, the method needs to...

Exploring green organic solvents is a global demand. Most of the currently used solvents pose some concerns regarding environmental sustainability and occupational health risks. In this work, propylene glycol was employed for the first time as a gree...