Comparison of Decidual Vasculopathy in Central and Peripheral Regions of Placenta with Implication of Lateral Growth and Spiral Artery Remodeling
Pathology, New York Presbyterian–Brooklyn Methodist Hospital, Brooklyn, NY 11215, USA
Reprod. Med. 2020, 1(3), 158-168; https://doi.org/10.3390/reprodmed1030012
Received: 10 September 2020
/
Revised: 28 September 2020
/
Accepted: 29 September 2020
/
Published: 2 October 2020
(This article belongs to the Special Issue Preeclampsia: Pathogenesis, Diagnosis and Treatment)
Decidual vasculopathy at late gestation was shown to be associated with spiral artery remodeling at implantation. Dramatic decidual vascular transformation from early to late stage pregnancy suggests a dynamic spatiotemporal relationship between the various vascular components in spiral artery remodeling and decidual vasculopathy. The central and peripheral portions of 105 placentas with decidual vasculopathy at term were examined with or without preeclampsia to see if temporal vascular regeneration was present. Central and peripheral vasculopathy and central and peripheral regeneration were compared. The peripheral portion showed more decidual vasculopathy (88 of total 105, 83.8%) than central portion (72 of total 105, 68.6%, p < 0.0001). However, central portion showed more vascular regeneration (51 of total 105, 48.6%) than the peripheral portion (23 of total 105, 21.9%, p < 0.0001). There was no difference in vasculopathy or regeneration with or without preeclampsia. Spiral artery remodeling is non-synchronous during placental growth and vascular regeneration. This spatiotemporal sequence may help interpretation of morphologic changes of decidual vasculopathy.
View Full-Text
Keywords:
decidual vasculopathy; spiral artery remodeling; placenta lateral growth; maternal vascular regeneration
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Zhang, P. Comparison of Decidual Vasculopathy in Central and Peripheral Regions of Placenta with Implication of Lateral Growth and Spiral Artery Remodeling. Reprod. Med. 2020, 1, 158-168. https://doi.org/10.3390/reprodmed1030012
AMA Style
Zhang P. Comparison of Decidual Vasculopathy in Central and Peripheral Regions of Placenta with Implication of Lateral Growth and Spiral Artery Remodeling. Reproductive Medicine. 2020; 1(3):158-168. https://doi.org/10.3390/reprodmed1030012
Chicago/Turabian StyleZhang, Peilin. 2020. "Comparison of Decidual Vasculopathy in Central and Peripheral Regions of Placenta with Implication of Lateral Growth and Spiral Artery Remodeling" Reproductive Medicine 1, no. 3: 158-168. https://doi.org/10.3390/reprodmed1030012
Find Other Styles
