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Reports, Volume 6, Issue 3
September 2023 - 14 articles
Cover Story: For the past 60 years, the dopamine hypothesis of schizophrenia has been the operating system of Western psychiatry. It is now time to step back and evaluate the results. Despite decades of treatment with postsynaptic dopamine blockers, schizophrenia outcome studies reveal less than 15% sustained recovery for patients, with long-term public psychiatric facilities, such as State hospitals, continuing to exist. What if excessive dopamine transmission in the brain is not the cause of schizophrenia? What if gut microbes translocate into the host circulation and the immune system response damages brain cells? The microbial translocation hypothesis opens new intervention avenues, including Aryl Hydrocarbon antagonists, recombinant IL-22, and vagal stimulation. View this paper
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Reports - ISSN 2571-841X