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The Mercapturomic Profile of Health and Non-Communicable Diseases

1
CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-006 Lisboa, Portugal
2
Centro de Química Estrutural, Instituto Superior Técnico, ULisboa, 1049-001 Lisboa, Portugal
*
Author to whom correspondence should be addressed.
These authors contributed to this manuscript equally.
High-Throughput 2019, 8(2), 10; https://doi.org/10.3390/ht8020010
Received: 31 March 2019 / Revised: 15 April 2019 / Accepted: 17 April 2019 / Published: 23 April 2019
(This article belongs to the Special Issue Adductomics: Elucidating the Environmental Causes of Disease)
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Abstract

The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases. View Full-Text
Keywords: mercapturate pathway; cysteine-S-conjugates; chronic inflammation; N-acetyl-transferase 8; cysteinyl-leukotrienes; dopamine; estrogen; disulfides; metabolomics; biomarkers mercapturate pathway; cysteine-S-conjugates; chronic inflammation; N-acetyl-transferase 8; cysteinyl-leukotrienes; dopamine; estrogen; disulfides; metabolomics; biomarkers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Gonçalves-Dias, C.; Morello, J.; Semedo, V.; Correia, M.J.; Coelho, N.R.; Monteiro, E.C.; Antunes, A.M.M.; Pereira, S.A. The Mercapturomic Profile of Health and Non-Communicable Diseases. High-Throughput 2019, 8, 10.

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