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Clinical and Translational Neuroscience is published by MDPI from Volume 5 Issue 2 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with SAGE.
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Review

Aquaporins in Neurological Disorders

by
Lorenz Hirt
1,2,*,
Melanie Price
1,2,
Corinne Benakis
3 and
Jérôme Badaut
4,5
1
Neurology Service, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois, rue du Bugnon 46, BH07-414, 1011 Lausanne, Switzerland
2
Centre de Recherche en Neurosciences (CRN), CHUV, 1011 Lausanne, Switzerland
3
Institute for Stroke and Dementia Research (ISD), 81377 Munich, Germany
4
CNRS UMR 5287, INCIA, University of Bordeaux, 33076 Bordeaux, France
5
Department of Basic Science, Loma Linda University, Loma Linda, CA 92354, USA
*
Author to whom correspondence should be addressed.
Clin. Transl. Neurosci. 2018, 2(1), 3; https://doi.org/10.1177/2514183x17752902
Submission received: 24 July 2017 / Accepted: 30 October 2017 / Published: 7 February 2018

Abstract

Aquaporins (AQPs) are water channel molecules that allow the passage of water through the lipid bilayers of cell membranes. AQP1, AQP4 and AQP9 are expressed in the central nervous system and AQP4 is well known as the target of auto-antibodies in Devic’s neuromyelitis optica. The role of AQPs in facilitating water movements suggests a link with oedema formation and resolution in the brain. Furthermore, AQPs are also involved in process formation in glial cells with a close link to neuroinflammation. This mini-review gives an overview of what is currently known about the role of AQPs in different neurological disorders.
Keywords: Aquaporin; water channels; AQP4; AQP9; AQP1; cerebral oedema; neurological disorders; astrocytic end feet Aquaporin; water channels; AQP4; AQP9; AQP1; cerebral oedema; neurological disorders; astrocytic end feet

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MDPI and ACS Style

Hirt, L.; Price, M.; Benakis, C.; Badaut, J. Aquaporins in Neurological Disorders. Clin. Transl. Neurosci. 2018, 2, 3. https://doi.org/10.1177/2514183x17752902

AMA Style

Hirt L, Price M, Benakis C, Badaut J. Aquaporins in Neurological Disorders. Clinical and Translational Neuroscience. 2018; 2(1):3. https://doi.org/10.1177/2514183x17752902

Chicago/Turabian Style

Hirt, Lorenz, Melanie Price, Corinne Benakis, and Jérôme Badaut. 2018. "Aquaporins in Neurological Disorders" Clinical and Translational Neuroscience 2, no. 1: 3. https://doi.org/10.1177/2514183x17752902

APA Style

Hirt, L., Price, M., Benakis, C., & Badaut, J. (2018). Aquaporins in Neurological Disorders. Clinical and Translational Neuroscience, 2(1), 3. https://doi.org/10.1177/2514183x17752902

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