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A One-Pot Process for the Synthesis of Alkyne-3-tretrazolyl-tetrazolo [1,5-a] Quinolines

Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, C.P. 36050, Guanajuato, Gto., Mexico
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Presented at the 22nd International Electronic Conference on Synthetic Organic Chemistry, 15 November- 15 December 2018; Available Online: https://sciforum.net/conference/ecsoc-22.
Proceedings 2019, 9(1), 42; https://doi.org/10.3390/ecsoc-22-05798
Published: 14 November 2018
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Abstract

An efficient synthesis of alkyne-3-tetrazolyl-tetrazolo[1,5-a] quinolones via a one-pot isocyanide-based multicomponent reaction (IMCR) process: I-MCR Ugi-azide/SNAr/ring-chain azido tautomerization was performed under eco-friendly conditions. We report the one-pot synthesis of tris-heterocycles containing a tetrazolo[1,5-a] quinoline connected to a 1,5-disubstituted-tetrazole (1,5-DS-T). The synthesis of these compounds is of great interest in synthetic and medicinal chemistry because these heterocycles are considered privileged scaffolds and their preparation and evaluation may lead to the discovery of novel bioactive molecules.
Keywords: isocyanide based multicomponent reaction; Ugi-azide; tetrazolo [1,5-a] quinolones; ring-chain azido tautomerization; one-pot process; alkyne moiety isocyanide based multicomponent reaction; Ugi-azide; tetrazolo [1,5-a] quinolones; ring-chain azido tautomerization; one-pot process; alkyne moiety
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ramírez-López, S.C.; Unnamatla, M.B.; Gámez-Montaño, R. A One-Pot Process for the Synthesis of Alkyne-3-tretrazolyl-tetrazolo [1,5-a] Quinolines. Proceedings 2019, 9, 42.

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