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Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process
 
 
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Proceeding Paper

A One-Pot Process for the Synthesis of Alkyne-3-tretrazolyl-tetrazolo [1,5-a] Quinolines †

by
Sandra C. Ramírez-López
,
M.V. Basavanag Unnamatla
and
Rocío Gámez-Montaño
*
Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, C.P. 36050, Guanajuato, Gto., Mexico
*
Author to whom correspondence should be addressed.
†
Presented at the 22nd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2018; Available Online: https://sciforum.net/conference/ecsoc-22.
Proceedings 2019, 9(1), 42; https://doi.org/10.3390/ecsoc-22-05798
Published: 14 November 2018
(This article belongs to the Proceedings of 22nd International Electronic Conference on Synthetic Organic Chemistry)
Versions Notes

Abstract

An efficient synthesis of alkyne-3-tetrazolyl-tetrazolo[1,5-a] quinolones via a one-pot isocyanide-based multicomponent reaction (IMCR) process: I-MCR Ugi-azide/SNAr/ring-chain azido tautomerization was performed under eco-friendly conditions. We report the one-pot synthesis of tris-heterocycles containing a tetrazolo[1,5-a] quinoline connected to a 1,5-disubstituted-tetrazole (1,5-DS-T). The synthesis of these compounds is of great interest in synthetic and medicinal chemistry because these heterocycles are considered privileged scaffolds and their preparation and evaluation may lead to the discovery of novel bioactive molecules.
Keywords: isocyanide based multicomponent reaction; Ugi-azide; tetrazolo [1,5-a] quinolones; ring-chain azido tautomerization; one-pot process; alkyne moiety isocyanide based multicomponent reaction; Ugi-azide; tetrazolo [1,5-a] quinolones; ring-chain azido tautomerization; one-pot process; alkyne moiety

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MDPI and ACS Style

Ramírez-López, S.C.; Unnamatla, M.V.B.; Gámez-Montaño, R. A One-Pot Process for the Synthesis of Alkyne-3-tretrazolyl-tetrazolo [1,5-a] Quinolines. Proceedings 2019, 9, 42. https://doi.org/10.3390/ecsoc-22-05798

AMA Style

Ramírez-López SC, Unnamatla MVB, Gámez-Montaño R. A One-Pot Process for the Synthesis of Alkyne-3-tretrazolyl-tetrazolo [1,5-a] Quinolines. Proceedings. 2019; 9(1):42. https://doi.org/10.3390/ecsoc-22-05798

Chicago/Turabian Style

Ramírez-López, Sandra C., M.V. Basavanag Unnamatla, and Rocío Gámez-Montaño. 2019. "A One-Pot Process for the Synthesis of Alkyne-3-tretrazolyl-tetrazolo [1,5-a] Quinolines" Proceedings 9, no. 1: 42. https://doi.org/10.3390/ecsoc-22-05798

APA Style

Ramírez-López, S. C., Unnamatla, M. V. B., & Gámez-Montaño, R. (2019). A One-Pot Process for the Synthesis of Alkyne-3-tretrazolyl-tetrazolo [1,5-a] Quinolines. Proceedings, 9(1), 42. https://doi.org/10.3390/ecsoc-22-05798

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