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Proceeding Paper

Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process †

by
Sandra C. Ramírez-López
,
M. V. Basavanag Unnamatla
and
Rocío Gámez-Montaño
*
Departamento de Química, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, C.P. 36050, Guanajuato, Gto., Mexico
*
Author to whom correspondence should be addressed.
†
Presented at the 22nd International Electronic Conference on Synthetic Organic Chemistry, 15 November– 15 December 2018; Available Online: https://sciforum.net/conference/ecsoc-22.
Proceedings 2019, 9(1), 41; https://doi.org/10.3390/ecsoc-22-05796
Published: 14 November 2018
(This article belongs to the Proceedings of 22nd International Electronic Conference on Synthetic Organic Chemistry)
Versions Notes

Abstract

A solvent-free and catalyst-free synthesis of fused bis-heterocycles containing imidazo[1,2-a]pyridine and tetrazolo[1,5-a]quinoline frameworks is reported via a one-pot process. This Groebke–Blackburn–Bienaymé reaction (GBBR)/SNAr/ring-chain azido tautomerization cascade proceeds under eco-friendly conditions. The tetrazolo[1,5-a]quinoline and imidazo[1,2-a]pyridine scaffolds are present in various compounds with interesting pharmacological properties and could lead to the discovery of novel bioactive molecules.
Keywords: isocyanide-based multicomponent reactions; Groebke–Blackburn–Bienaymé reaction; tetrazolo[1,5-a]quinolines; ring-chain azido tautomerization; one-pot process isocyanide-based multicomponent reactions; Groebke–Blackburn–Bienaymé reaction; tetrazolo[1,5-a]quinolines; ring-chain azido tautomerization; one-pot process

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MDPI and ACS Style

Ramírez-López, S.C.; Unnamatla, M.V.B.; Gámez-Montaño, R. Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process. Proceedings 2019, 9, 41. https://doi.org/10.3390/ecsoc-22-05796

AMA Style

Ramírez-López SC, Unnamatla MVB, Gámez-Montaño R. Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process. Proceedings. 2019; 9(1):41. https://doi.org/10.3390/ecsoc-22-05796

Chicago/Turabian Style

Ramírez-López, Sandra C., M. V. Basavanag Unnamatla, and Rocío Gámez-Montaño. 2019. "Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process" Proceedings 9, no. 1: 41. https://doi.org/10.3390/ecsoc-22-05796

APA Style

Ramírez-López, S. C., Unnamatla, M. V. B., & Gámez-Montaño, R. (2019). Solvent-Free Synthesis of Imidazo [1,2-a] pyridin-tetrazolo [1,5-a] Quinolines via an IMCR One-Pot Process. Proceedings, 9(1), 41. https://doi.org/10.3390/ecsoc-22-05796

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