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Open AccessExtended Abstract

Small Molecules as Potential Inhibitors of the 14-3-3/c-Abl Interaction for the Treatment of CML

1
Department of Biotechnology, Chemistry and Farmacy- Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
2
Medicinal Chemistry, Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit, AstraZeneca, SE-43183 Gothenburg, Sweden
3
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy
4
Consiglio Nazionale delle Ricerche, Istituto di Fisiologia Clinica and University of Siena, Via Fiorentina 1, 53100 Siena, Italy
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 17; https://doi.org/10.3390/proceedings2019022017
Published: 7 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
PDF [197 KB, uploaded 7 August 2019]
Note: In lieu of an abstract, this is an excerpt from the first page.

Excerpt

c-Abl is a tyrosine kinase implicated in the regulation of proliferation, adhesion, motility, and
cell survival [...]
Keywords: 14-3-3; Protein-protein interactions; c-Abl; chronic myeloid leukemia (CML) 14-3-3; Protein-protein interactions; c-Abl; chronic myeloid leukemia (CML)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Iralde-Lorente, L.; Tassone, G.; Cau, Y.; Munier, C.; Franci, L.; Pozzi, C.; Angelucci, A.; Chiariello, M.; Perry, M.; Mangani, S.; Botta, M. Small Molecules as Potential Inhibitors of the 14-3-3/c-Abl Interaction for the Treatment of CML. Proceedings 2019, 22, 17.

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