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In Silico Design of E3 Ubiquitin-Protein Ligase NEDD4-1 Inhibitors: An Alternative Approach for Targeting the MAPK Pathway in Cancer Therapy

1
Institute of Chemistry of Molecular Recognition (National Research Council), 00168 Rome, Italy
2
Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, 00168 Rome, Italy
3
Sapienza University of Rome, 00100 Rome, Italy
4
Institute of Genomic Medicine, Catholic University of Rome, 00168 Rome, Italy
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 10; https://doi.org/10.3390/proceedings2019022010
Published: 7 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
PDF [176 KB, uploaded 7 August 2019]
Note: In lieu of an abstract, this is an excerpt from the first page.

Excerpt

Among all the several targets in common use in the antitumor therapies, the pharmacologic
inhibition of the MAPK (Mitogen Activated Protein Kinase) pathway represents an efficient
therapeutic approach [1]. [...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Pirolli, D.; Righino, B.; Tropea, B.; Gurrieri, F.; Sangiorgi, E.; Rosa, M.C.D. In Silico Design of E3 Ubiquitin-Protein Ligase NEDD4-1 Inhibitors: An Alternative Approach for Targeting the MAPK Pathway in Cancer Therapy. Proceedings 2019, 22, 10.

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