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Proceeding Paper

Portable Immunosensor Based on Extended Gate—Field Effect Transistor for Rapid, Sensitive Detection of Cancer Markers

1
Biophysics & Nanoscience Centre, DEB, Università degli Studi della Tuscia, Largo dell’Università, 01100 Viterbo, Italy
2
CNR-IRET, Institute of Research on Terrestrial Ecosystems, Via Marconi 2, 05010 Porano (TR), Italy
3
CNR-IMM, Institute for Microelectronics and Microsystems, Via Monteroni, 73100 Lecce, Italy
4
CMM-FBK, “Bruno Kessler” Foundation, Via Sommarive 18, 38123 Trento, Italy
5
Synergie Cad Instruments, via Milano 15I/15L, 25032 Chiari (BS), Italy
*
Author to whom correspondence should be addressed.
Presented at the 7th International Symposium on Sensor Science, Napoli (Italy), 9–11 May 2019.
Proceedings 2019, 15(1), 32; https://doi.org/10.3390/proceedings2019015032
Published: 30 July 2019
(This article belongs to the Proceedings of 7th International Symposium on Sensor Science)
We present an immunosensor for the rapid and sensitive detection of the p53 oncosuppressor protein and of its mutated form p53R175H, which are both valuable cancer biomarkers. The sensor is based on the accurate measurement of the source-drain current variation of a metal oxide semiconductor field-effect transistor, as due to the gate potential changing arising from charge release upon the selective capture of a biomarker by the partner immobilized on a sensing surface connected to the gate electrode. A suitable microelectronic system is implemented to combine high current resolution, which is needed to be competitive with standard immunoassays, with compact dimensions of the final sensor device.
Keywords: biosensor; immunosensor; cancer markers; EG-FET biosensor; immunosensor; cancer markers; EG-FET
MDPI and ACS Style

Baldacchini, C.; Bizzarri, A.R.; Montanarella, A.F.; Pascali, C.D.; Lorenzelli, L.; Parretti, F.; Cagliesi, R.; Francioso, L.; Cannistraro, S. Portable Immunosensor Based on Extended Gate—Field Effect Transistor for Rapid, Sensitive Detection of Cancer Markers. Proceedings 2019, 15, 32. https://doi.org/10.3390/proceedings2019015032

AMA Style

Baldacchini C, Bizzarri AR, Montanarella AF, Pascali CD, Lorenzelli L, Parretti F, Cagliesi R, Francioso L, Cannistraro S. Portable Immunosensor Based on Extended Gate—Field Effect Transistor for Rapid, Sensitive Detection of Cancer Markers. Proceedings. 2019; 15(1):32. https://doi.org/10.3390/proceedings2019015032

Chicago/Turabian Style

Baldacchini, Chiara, Anna Rita Bizzarri, Antonino Francesco Montanarella, Chiara De Pascali, Leandro Lorenzelli, Francesco Parretti, Roger Cagliesi, Luca Francioso, and Salvatore Cannistraro. 2019. "Portable Immunosensor Based on Extended Gate—Field Effect Transistor for Rapid, Sensitive Detection of Cancer Markers" Proceedings 15, no. 1: 32. https://doi.org/10.3390/proceedings2019015032

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