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Volume 128, IECE 2025
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Proceedings, 2025, INT-DOC-RES

International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration

Timisoara, Romania | 7–9 July 2025

Volume Editors:
Corina Danciu, Victor Babeș University of Medicine and Pharmacy Timișoara, Romania
Lucreția Udrescu, Victor Babeș University of Medicine and Pharmacy Timișoara, Romania
Marius Mioc, Victor Babeș University of Medicine and Pharmacy Timișoara, Romania
Iulia Pînzaru, Victor Babeș University of Medicine and Pharmacy Timișoara, Romania
Cristina Trandafirescu, Victor Babeș University of Medicine and Pharmacy Timișoara, Romania
Codruța Șoica, Victor Babeș University of Medicine and Pharmacy Timișoara, Romania
Cristina Adriana Dehelean, Victor Babeș University of Medicine and Pharmacy Timișoara, Romania

Number of Papers: 26
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Cover Story (view full-size image): The inaugural edition of the International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration, held from July 7–9, [...] Read more.
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Research

2 pages, 139 KB  
Abstract
Assessment of the Antiproliferative, Cytotoxic, Antimigratory, Antimicrobial, and Irritative Potential of Novel Phosphonate Derivatives of Betulinic Acid
by Diana Ungureanu (Similie), Larisa Bora, Ștefana Avram, Māris Turks, Delia Muntean and Corina Danciu
Proceedings 2025, 127(1), 1; https://doi.org/10.3390/proceedings2025127001 - 16 Sep 2025
Viewed by 243
Abstract
Introduction: Plants have long been a valuable source for the discovery of therapeutic remedies [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 125 KB  
Abstract
Design and Evaluation of Advanced Nanocarriers for Targeted Delivery of Antitumor Agents: From Physicochemical Characterization to Preclinical Validation
by Iasmina-Alexandra Predescu and Iulia Pinzaru
Proceedings 2025, 127(1), 2; https://doi.org/10.3390/proceedings2025127002 - 16 Sep 2025
Viewed by 240
Abstract
The continuous evolution of nanotechnology has led to the development of innovative strategies for cancer treatment, particularly through nanosystems designed to deliver antitumor agents in a targeted and efficient manner [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 174 KB  
Abstract
Clinical Relevance of Drug–Drug Interactions in Hemato-Oncology with Focus on Contrast Media
by Sabina-Oana Vasii, Daniel-Claudiu Malița, Florin Bîrsășteanu, Ioana Ioniță and Lucreția Udrescu
Proceedings 2025, 127(1), 3; https://doi.org/10.3390/proceedings2025127003 - 17 Sep 2025
Viewed by 219
Abstract
Background [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 170 KB  
Abstract
Correlative Assessment of Oenothera biennis L. Using In Vitro and In Ovo Models
by Ramona Fecker, Larisa Bora, Ștefana Avram, Daliana Minda, Ioana Zinuca Magyari-Pavel, Elena-Alina Moacă, Cristina Adriana Dehelean and Corina Danciu
Proceedings 2025, 127(1), 4; https://doi.org/10.3390/proceedings2025127004 - 17 Sep 2025
Viewed by 221
Abstract
The combination of commercially available Oenothera biennis L. and Helianthus annuus L. oils (OBO-SFO) was evaluated in terms of oxidative stability and biological safety [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 161 KB  
Abstract
Maslinic Acid Nanoemulsion: In Vitro and In Ovo Assessment
by Ioana Zinuca Magyari-Pavel, Diana Ungureanu (Similie), Ștefana Avram, Elena-Alina Moacă, Larisa Bora, Daliana Minda, Lavinia Vlaia, Cristina Adriana Dehelean and Corina Danciu
Proceedings 2025, 127(1), 5; https://doi.org/10.3390/proceedings2025127005 - 18 Sep 2025
Viewed by 174
Abstract
Nowadays, natural products are highly investigated in cancer research due to their wide distribution, numerous beneficial effects, and minimal side effects [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 164 KB  
Abstract
Moroccan Pomegranate Peel Extract: Phytochemical Profile and Bioactivity Evaluation for Oral Health
by Larisa Bora, Ștefana Avram, Daliana Minda, Ioana Zinuca Magyari-Pavel, Zineb Bennani, Ioana Maria Carmen Ienașcu, Adina Căta, Delia Muntean and Corina Danciu
Proceedings 2025, 127(1), 6; https://doi.org/10.3390/proceedings2025127006 - 19 Sep 2025
Viewed by 231
Abstract
Pomegranate peel, a by-product traditionally used for oral health in Mediterranean medicine, represents a sustainable natural alternative to synthetic oral care products [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 177 KB  
Abstract
Drug–Drug Interactions in COPD Therapy: A Community Pharmacy Study
by Maria-Medana Drăgoi, Sebastian-Mihai Ardelean and Lucreția Udrescu
Proceedings 2025, 127(1), 7; https://doi.org/10.3390/proceedings2025127007 - 18 Sep 2025
Viewed by 237
Abstract
Background: [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 176 KB  
Abstract
In Vitro and In Ovo Evaluation of Water-Soluble Extract from Coffea arabica Green Seeds—A Phytotherapeutic Perspective in Cutaneous Oncology
by Grațiana Ruse, Elena-Alina Moacă, Alexandra Semenescu, Ştefana Avram, Andreea Munteanu, Alex-Robert Jîjie and Diana-Simona Tchiakpe-Antal
Proceedings 2025, 127(1), 8; https://doi.org/10.3390/proceedings2025127008 - 19 Sep 2025
Viewed by 175
Abstract
Introduction: Green coffee (Coffea arabica L [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 170 KB  
Abstract
Improving Anticancer Activity of Flubendazole via Inclusion Complexes with Randomly Methylated β-Cyclodextrin
by Ramona Pârvănescu, Tamara Maksimović, Codruța Șoica and Cristina Trandafirescu
Proceedings 2025, 127(1), 9; https://doi.org/10.3390/proceedings2025127009 - 19 Sep 2025
Viewed by 221
Abstract
Flubendazole is a benzimidazole derivative used as an anthelmintic [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 179 KB  
Abstract
Co-Crystallization Adducts of Carvedilol with Carboxylic Acids: Design and Characterization
by Ema-Teodora Nițu, Luciana Buliga, Ioana Mitrofan, Amalia Ridichie, Cornelia Muntean, Ionuţ Ledeţi, Adriana Ledeți and Laura Sbârcea
Proceedings 2025, 127(1), 10; https://doi.org/10.3390/proceedings2025127010 - 22 Sep 2025
Viewed by 170
Abstract
Carvedilol (CARV) belongs to the group of non-selective beta and alpha-1 adrenergic receptor antagonists and is indicated for hypertension and chronic heart failure [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 184 KB  
Abstract
Elemental Composition and Potential Nutraceutical Value of Taxus baccata L. Arils: A Preliminary Safety Assessment
by Alex-Robert Jîjie, Elena-Alina Moacă, George Andrei Drăghici, Oana Andrada Iftode, Dalia Pătrașcu, Ionela Daliana Minda, Laura Sbârcea, Grațiana Ruse and Cristina Adriana Dehelean
Proceedings 2025, 127(1), 11; https://doi.org/10.3390/proceedings2025127011 - 24 Sep 2025
Viewed by 187
Abstract
Introduction: Taxus baccata L [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 139 KB  
Abstract
Synthetically Enhanced Betulin-Based Triazoles as Promising Anticancer Agents
by Alexandra Prodea, Oana Eşanu, Marius Mioc and Codruța Șoica
Proceedings 2025, 127(1), 12; https://doi.org/10.3390/proceedings2025127012 - 24 Sep 2025
Viewed by 146
Abstract
This study presents the synthesis and biological evaluation of novel betulin-based 1,2,4-triazole derivatives targeting human cancer cells [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 126 KB  
Abstract
Evaluation of the Anticancer Properties of Cedrus atlantica Essential Oil on Skin and Colorectal Cancer Cell
by Oana-Maria Eșanu, Codruța Șoica and Marius Mioc
Proceedings 2025, 127(1), 13; https://doi.org/10.3390/proceedings2025127013 - 24 Sep 2025
Viewed by 164
Abstract
Skin and colorectal cancers are among the most pressing global health concerns, highlighting the urgent need for the development of novel therapeutic strategies [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 122 KB  
Abstract
Computational Exploration of Betulinic Acid Hybrids as Dual BCL-2/BCL-XL Inhibitors
by Elisabeta P. Atyim, Marius Mioc and Codruța Șoica
Proceedings 2025, 127(1), 14; https://doi.org/10.3390/proceedings2025127014 - 25 Sep 2025
Viewed by 132
Abstract
Betulinic acid (BA), a lupane-type triterpene widely studied for its selective cytotoxicity against malignancies [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 132 KB  
Abstract
Digoxin as a Potential Anticancer Agent in Melanoma Treatment
by Ștefania-Irina Dumitrel, Andreea Cristea, Andreea Smeu, Sergio Liga and Cristina-Adriana Dehelean
Proceedings 2025, 127(1), 15; https://doi.org/10.3390/proceedings2025127015 - 25 Sep 2025
Viewed by 179
Abstract
Cutaneous melanoma (CM) is one of the most aggressive and lethal forms of skin cancer, characterized by a high rate of proliferation, marked local invasion, and high metastatic potential [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 171 KB  
Abstract
Systemic Drug–Drug Interactions in Dental Care: Patterns, Risks, and Clinical Management Strategies
by Daiana Colibășanu, Sebastian Mihai Ardelean, Florina-Diana Goldiș, Maria-Medana Drăgoi, Sabina-Oana Vasii, Tamara Maksimović, Șerban Colibășanu, Codruța Șoica and Lucreția Udrescu
Proceedings 2025, 127(1), 16; https://doi.org/10.3390/proceedings2025127016 - 26 Sep 2025
Viewed by 173
Abstract
In the context of an aging population and the increasing number of patients receiving multiple medications, modern dental practice faces the growing challenge of drug–drug interactions (DDIs) [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 178 KB  
Abstract
Datura stramonium L.—The Toxicological Aspects of an Alternative Drug of Abuse
by Dalia-Maria Horşia (Pătrașcu), Noni Ștefan Marcu, Alex-Robert Jîjie, Elena-Alina Moacă, Oana Andrada Iftode and Cristina Adriana Dehelean
Proceedings 2025, 127(1), 17; https://doi.org/10.3390/proceedings2025127017 - 26 Sep 2025
Viewed by 427
Abstract
Datura stramonium, commonly known as jimsonweed or Devil’s trumpet, belongs to the Solanaceae family and has a long history of medicinal and toxicological importance [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
3 pages, 183 KB  
Abstract
Drug–Drug Interactions in Outpatient Psychiatry: From Interaction Profiles to Smart Monitoring
by Florina-Diana Goldiș, Răzvan Păiușan, Mihai Udrescu and Lucreția Udrescu
Proceedings 2025, 127(1), 18; https://doi.org/10.3390/proceedings2025127018 - 26 Sep 2025
Viewed by 216
Abstract
Objective [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 143 KB  
Abstract
Study on In Vitro Release and Permeation of Oxymetazoline Hydrochloride from Topical Cream and Hydrogel Vehicles
by Ştefania-Adriana Colgiu, Ana-Maria Cotan, Ioana-Viorica Olariu, Vicenţiu Vlaia, Georgeta Coneac and Lavinia Vlaia
Proceedings 2025, 127(1), 19; https://doi.org/10.3390/proceedings2025127019 - 25 Sep 2025
Viewed by 152
Abstract
Background: [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 125 KB  
Abstract
The Anti-Aging Effects of Polyphenols: The Mitochondrial Perspective
by Tamara Maksimović, Alexandra Mioc and Codruța Șoica
Proceedings 2025, 127(1), 20; https://doi.org/10.3390/proceedings2025127020 - 27 Sep 2025
Viewed by 324
Abstract
Aging is characterized by a progressive decline in organ and cellular functions, followed by greater susceptibility to various diseases and death [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 128 KB  
Abstract
Rational Design of Betulin-Based Hybrids as Multi-Target Inhibitors of Anti-Apoptotic BCL Proteins
by Mihaela Čoban and Marius Mioc
Proceedings 2025, 127(1), 21; https://doi.org/10.3390/proceedings2025127021 - 28 Sep 2025
Viewed by 143
Abstract
Triterpenes such as betulin are intensively studied for their intrinsic pro-apoptotic effects in cancer, providing a privileged scaffold for anti-tumor drug design [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 161 KB  
Abstract
Geranium robertianum L. as a Source of Bioactive Compounds: From Pharmacognostic Characterization to Biological Relevance
by Diana Haj Ali, Larisa Bora, Ștefana Avram, Daliana Minda, Ioana Zinuca Magyari-Pavel, Adina Cata, Ioana Ienascu, Cristina Adriana Dehelean and Corina Danciu
Proceedings 2025, 127(1), 22; https://doi.org/10.3390/proceedings2025127022 - 30 Sep 2025
Viewed by 189
Abstract
Geranium robertianum L [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 123 KB  
Abstract
The Integration of Nanoparticle-Based Drug Delivery and AI-Driven Pharmacogenomics in the Treatment of Prostate Adenocarcinoma
by Marinela Nicolescu and Iulia Pinzaru
Proceedings 2025, 127(1), 23; https://doi.org/10.3390/proceedings2025127023 - 10 Oct 2025
Viewed by 167
Abstract
Prostate adenocarcinoma remains a significant therapeutic challenge, particularly in its advanced and treatment-resistant forms [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 146 KB  
Abstract
Antioxidant Activity of 2% G. glabra L. Hydrogels for Potential Use in Oxidative Stress-Related Skin Conditions
by Iulia Semenescu, Ștefana Avram, Larisa Bora, Szilvia Berkó, Daliana Minda and Corina Danciu
Proceedings 2025, 127(1), 24; https://doi.org/10.3390/proceedings2025127024 - 15 Oct 2025
Abstract
Glycyrrhiza, commonly known as licorice, has been extensively studied for its many pharmacological properties, with recent research also focused on its potential dermatological applications [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 150 KB  
Abstract
Praseodymium-Doped Cobalt Ferrite Nanoparticles: Novel Selective Anticancer Agents with Magnetic Modulation
by Slavița Rotunjanu, Roxana Racoviceanu and Codruța Șoica
Proceedings 2025, 127(1), 25; https://doi.org/10.3390/proceedings2025127025 - 14 Oct 2025
Abstract
In the pursuit of multifunctional nanomaterials for oncological applications, cobalt ferrite nanoparticles doped with praseodymium (CoFe2−yPryO4, y = 0–0[...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
2 pages, 133 KB  
Abstract
Targeting Melanoma via Drug Repurposing: Investigating Melatonin Synergy and Melanin-Driven Resistance in 2D Cell Line Models
by Eliza Szabo and Iulia Andreea Pinzaru
Proceedings 2025, 127(1), 26; https://doi.org/10.3390/proceedings2025127026 - 14 Oct 2025
Abstract
Melanoma is a highly aggressive form of skin cancer known for its swift acquisition of resistance to treatment, particularly therapies targeting the Mitogen-Activated Protein Kinase (MAPK) signaling cascade [...] Full article
(This article belongs to the Proceedings of International Conference on Interdisciplinary Approaches and Emerging Trends in Pharmaceutical Doctoral Research: Innovation and Integration)
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